ID   A0A0D2HGW1_9EURO        Unreviewed;       775 AA.
AC   A0A0D2HGW1;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   13-SEP-2023, entry version 29.
DE   SubName: Full=Acetoacetate-CoA ligase {ECO:0000313|EMBL:KIW83684.1};
GN   ORFNames=Z517_02930 {ECO:0000313|EMBL:KIW83684.1};
OS   Fonsecaea pedrosoi CBS 271.37.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW83684.1, ECO:0000313|Proteomes:UP000053029};
RN   [1] {ECO:0000313|EMBL:KIW83684.1, ECO:0000313|Proteomes:UP000053029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW83684.1,
RC   ECO:0000313|Proteomes:UP000053029};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN846970; KIW83684.1; -; Genomic_DNA.
DR   RefSeq; XP_013287492.1; XM_013432038.1.
DR   AlphaFoldDB; A0A0D2HGW1; -.
DR   STRING; 1442368.A0A0D2HGW1; -.
DR   GeneID; 25302420; -.
DR   VEuPathDB; FungiDB:Z517_02930; -.
DR   HOGENOM; CLU_000022_3_3_1; -.
DR   OrthoDB; 45466at2759; -.
DR   Proteomes; UP000053029; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR   PANTHER; PTHR42921:SF4; ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770); 1.
DR   PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:KIW83684.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        207..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          157..548
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   REGION          23..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          753..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   775 AA;  85973 MW;  A192848B6D4A7165 CRC64;
     MPSESPASCN AVGLPMKYCS KQYRDQAKRT LDSPGTSSSS STPSRNQNPS SSTDSNSTSL
     PTPLWTPADP EAPPMSRYRQ HVNTKFSQSL RDSHELHSWT VQNPHQFWID LYEYCGIVPS
     LPKHTKLAYN PKARLRDIPT FFPGLRLNYA ENVLVPNAAA NPNAVALVGL RENRLDDPEE
     ITWAELTELV RVARSAMVRR GIKKGDVVAG LMANSVWIIV LFLATASIGA IFTSVSPDLG
     VSGCVSRFAQ VEPKWLFADV DVAVRGTRPS MLGKVMQVLK ALPAAKAKPR LVFVPTCHRP
     HRQQHMDYIK PVGGAISLHE FLTKARAGDK LTYTRVPTDH PLVIVYSSGT TGEPKCIVSP
     HMSVLNYKKI SLLHNGLGPG STVFQFSSTS WILWNVMNGH LSVGAKVVCY DGGALHPDPS
     TMLRICAQFR ATYWGTSPRY LLELEQSGIR PDAFDLSRLA LVTTTGATLT GEQFHWFYRA
     FPRRIHLSSV AGGTDIASSW IATNPAGPVY ANEMQMWALG HDCDILDSET GRSCAAEGRP
     GELVCRKPFP SMPCRFWGDT PDHRKYREAY FEKFPLSNNS TDKTAAADGE EYLDVWAQHD
     FIVMNPLTKG LQILGRSDGV LNPSGIRFGS SEVYNIVEGP QFNTLISDTL CVGRRRAHDK
     DETVFLFVVM APGHDADFTP GLVEQLRTAI REGLSPRHVP KFIEQVREIP YTVNGKKVEV
     AVKRVISGQV VKTSSTVRNP ACLAEYERFR DLERAPQRQR QQQQQQTGRR GMAKL
//