ID A0A0D2K8N3_9CHLO Unreviewed; 1012 AA.
AC A0A0D2K8N3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=26S proteasome non-ATPase regulatory subunit 1 homolog {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=MNEG_1396 {ECO:0000313|EMBL:KIZ06553.1};
OS Monoraphidium neglectum.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Selenastraceae; Monoraphidium.
OX NCBI_TaxID=145388 {ECO:0000313|EMBL:KIZ06553.1, ECO:0000313|Proteomes:UP000054498};
RN [1] {ECO:0000313|EMBL:KIZ06553.1, ECO:0000313|Proteomes:UP000054498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAG 48.87 {ECO:0000313|EMBL:KIZ06553.1,
RC ECO:0000313|Proteomes:UP000054498};
RX PubMed=24373495; DOI=10.1186/1471-2164-14-926;
RA Bogen C., Al-Dilaimi A., Albersmeier A., Wichmann J., Grundmann M.,
RA Rupp O., Lauersen K.J., Blifernez-Klassen O., Kalinowski J., Goesmann A.,
RA Mussgnug J.H., Kruse O.;
RT "Reconstruction of the lipid metabolism for the microalga Monoraphidium
RT neglectum from its genome sequence reveals characteristics suitable for
RT biofuel production.";
RL BMC Genomics 14:926-926(2013).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SUBUNIT: Component of the 19S regulatory particle (RP/PA700) base
CC subcomplex of the 26S proteasome. The 26S proteasome is composed of a
CC core protease (CP), known as the 20S proteasome, capped at one or both
CC ends by the 19S regulatory particle (RP/PA700).
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
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DR EMBL; KK100357; KIZ06553.1; -; Genomic_DNA.
DR RefSeq; XP_013905572.1; XM_014050118.1.
DR AlphaFoldDB; A0A0D2K8N3; -.
DR STRING; 145388.A0A0D2K8N3; -.
DR GeneID; 25731474; -.
DR KEGG; mng:MNEG_1396; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000054498; Unassembled WGS sequence.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IEA:UniProtKB-UniRule.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 1.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 1.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000054498};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..348
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 787..970
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 271..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 836..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 836..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1012
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1012 AA; 106447 MW; 3F8992D5459AF678 CRC64;
MTSAAGLLTL LEEDNDTLKQ YALVNLDKVV HDFWFQISPS IASVEALYED EAFKKRELAA
LIASKVFYHL GELDSALTYA LGAGSYFDVN ENSEYVRTLV ARCLDQYFDS RRRQVEGGEE
SAEVDPRLVA VVERMVETAC QAGQWEQAVG VALEARRLDI LEAVVGRCPD KGSILSYALR
VTQRLVINRN FRHQVLRLLV RLAEESPSPD WVEVCQCLMF LDDAPRVAAI LGRLVEGSED
DALVAYQAAF DLVENEMQSF LQAVLDRLPK PPEPATPAPV AAAAPADGAA MDTDGAADAA
ADANGGAPPE AAAPSVDPAK AERLARLLGI LAGTTPIGLT LEFLYHNNHA DLQVLKNLKA
SVDARVSVLH SATILANALV HAGTSVDTFL RENLEWLSRA TNWAKFSATA GLGVIHRGQL
QQGKALLAPY LPRDGAGGSP YSEGGALYAL GLIAANHGAG HRTFLLESLR AAGSPVIQHG
ACLGLGLACL GTCDEEAFED LKNTLYTDDA VAGEAAGLAM GLLLCGSSSD KAQEMLAYAH
DTAHEKIIRG LALGLALTGY SREEGADALV EQMSGDQDPI LRWGAMFCLG LAYRGTANNN
AIARLLHCAV TDVSDDVRRA AVTSLGFVLM GNPEQCPRIV SLLAESFNPH VRYGAALAVG
IACAGSGGRE AVALLESMVA DSVDFVRQGV YIALALVLLQ QPEGRVEGLR KRLAKAVGDK
HEETMARMGA SVATGILDAG GRNVTVGLRS RSGYFRRTSV VGLALFTYHW YWHPVAHCLS
LAFTPSALIG LDASLRTPKL EVNVAARPSL FAYPPPLTVE ASKEVAKVEK AVLSTTAKAR
ERARKKELEK KDKEGGAAAE PAAKEGPSAM DTDDKAAAAA GSGAAAKEGG GAEGAVKAEG
EEGGGAGAAS APKKPDEPSS YVLTTPSRMT LQQVRFVSFA PDSRFVPVKR GAPPIGFVVL
RDTRPGEPVD YAASAAVGGV VGAAGGAAGA GPAAAPVQDA EPPPPAPFEF DG
//
