ID A0A0D2NHD0_GOSRA Unreviewed; 630 AA.
AC A0A0D2NHD0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
GN ORFNames=B456_005G231800 {ECO:0000313|EMBL:KJB32252.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB32252.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB32252.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00029430}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00029430}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004614}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Prevacuolar compartment membrane
CC {ECO:0000256|ARBA:ARBA00043947}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00043947}.
CC -!- SIMILARITY: Belongs to the VSR (BP-80) family.
CC {ECO:0000256|ARBA:ARBA00007038}.
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DR EMBL; CM001744; KJB32252.1; -; Genomic_DNA.
DR RefSeq; XP_012480142.1; XM_012624688.1.
DR AlphaFoldDB; A0A0D2NHD0; -.
DR STRING; 29730.A0A0D2NHD0; -.
DR EnsemblPlants; KJB32252; KJB32252; B456_005G231800.
DR GeneID; 105795178; -.
DR Gramene; KJB32252; KJB32252; B456_005G231800.
DR KEGG; gra:105795178; -.
DR eggNOG; ENOG502QSX2; Eukaryota.
DR OrthoDB; 305396at2759; -.
DR Proteomes; UP000032304; Chromosome 5.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd02125; PA_VSR; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR PANTHER; PTHR22702; PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22702:SF1; PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF02225; PA; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..630
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002248054"
FT TRANSMEM 572..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 503..517
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
SQ SEQUENCE 630 AA; 69911 MW; 274DD599EFF0B5DB CRC64;
MEIRRLHLLL LLQGFMLLSV MGNCYARFVV EKNSLRLTSP EKIKGTYDSA IGNFGIPQYG
GSMAGAVVYP KENQKGCKSF DDFGISFKSK PGALPAFVLV DRGDCFFALK VWNVQQAGAS
AVLVADDIQE ALITMDTPEE DRLAAKYIEN ITIPSALIEK KFGETLKKAI SGGDMVNVNL
DWRESVPHPD DRVEYELWTN SNDECGVKCD MLMEFLKDFK GAAQILEKGG YTQFTPHYIT
WYCPQAFSLS RQCKSQCINY GRYCAPDPEQ DFSSGYEGKD VVIENLRQLC VFKVANETNK
PWLWWDYVTD FQIRCPMKEK KYNKECADVV IRALGLDGKK IEKCMGDPNA DEDNPVLKEE
QEAQVGKGSR GDVTILPTLV VNDRQYRGKL AKGAVLKAIC AGFEETTEPA VCLSGDVETN
ECLDNNGGCW QDKATNLTAC KDTFRGRVCE CPLVDGVQFK GDGYSHCEAS GSGRCKINNG
GCWHDARDGH AYSACLDDGN GKCQCPPGFK GDGVKNCEDI DECKEKKACQ CPECSCKNTW
GSYECTCSGD LLYIRDHDTC ISKSGTEVRS SWAAVWVILI GLAMASGGAY LIYKYRLRSY
MDSEIRAIMA QYMPLDSQAE VPNHVSDSRA
//
