ID A0A0D2PY21_GOSRA Unreviewed; 1091 AA.
AC A0A0D2PY21;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=B456_001G127100 {ECO:0000313|EMBL:KJB09161.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB09161.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB09161.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR EMBL; CM001740; KJB09161.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2PY21; -.
DR EnsemblPlants; KJB09161; KJB09161; B456_001G127100.
DR Gramene; KJB09161; KJB09161; B456_001G127100.
DR Proteomes; UP000032304; Chromosome 1.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF929; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 37..162
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 182..506
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT COILED 515..546
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1091 AA; 127853 MW; D66306B3BBA9A1E9 CRC64;
MLVPQSDLTD NHQPMEVVAQ PEAANTVENQ PVEDPPSSRF TWRIENFSRL NAKKHYSEVF
VVGGYKWRIL LFPKGNNVDH LSMYLDVADS ASLPYGWSRY AQFSLAVVNQ IHNKYSIRKD
TQHQFNARES DWGFTSFMPL GELYDPCRGY LVNDTLIVEA EVVVRRIVDY WTYDSKKETG
YVGLKNQGAT CYMNSLLQTL YHIPYFRKAV YHMPTTENDM PSGSIPLALQ SLFYKLQYSD
SSVATKELTK SFGWDTHDSF MQHDVQELNR VLCEKLEDKM KGTVVEGTIQ QLFEGHHMNY
IECINVDYKS TRKESFYDLQ LDVKGCHDVY ASFDKYVEVE RLEGDNKYHA EQYGLQDAKK
GVLFIDFPPV LQLQLKRFEY DFMRDTMVKI NDRYEFPLQL DLDRDGGKYL SPDADRRVRN
LYTLHSVLVH SGGVHGGHYY AFIRPTLSDQ WYKFDDERVT KEDMKRALEE QYGGEEELPQ
TNPGFNNTPF KFTKYSNAYM LVYIRESDKD KIICNVDEKD IAEHLRERLK KEQEEKEHKK
KEKAEAHLYT IIKVARDDDL AGQIGKDIYF DLVDHDKVRS FRIQKQITFN VFKEEIAKEF
GIPVQFQRFW LWAKRQNHTY RPNRPLTPLE ETQSVGTLRE VSNKVHNAEL RLFLEVELGL
DLRPIAPPDK TKEDILLFFK HYNPEKEELR FVGRLFVKST GKPIEILSKL NKMAGYAPDE
EINLYEEIKF EPSVMCEPID KKITFRASQL EDGDIVCFQK SLPVESTEQF RYPDVPSFLE
YVHNRQIVHF RSLEKPKEDD FCLEMSRLYT YDDVVERVAQ KLGLNDPSKI RLTSHNCYSQ
QPKPQPIKYR GVDHLSDMLV HYNQTSDILY YEVLDIPLPE LQGLKTLKVA FHHATKDEVV
IHTIRLPKQS TVGDVINDLK TKVELSHPDA ELRLLEVFYH KIYKIFPPSE KIENINDQYW
TLRAEEIPEE EKNLGPNDRL IHVYHFTKET AQNQMQILNF GEPFFLVIHE GETLAEIKVR
IQKKLQVPDE DFAKWKFAFL SLGRPEYLQD SDIVSSRFQR RDVYGAWEQY LGLEHSDNAP
KRAYAANQDV T
//
