ID A0A0D2R2X6_GOSRA Unreviewed; 537 AA.
AC A0A0D2R2X6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=B456_004G235800 {ECO:0000313|EMBL:KJB26294.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB26294.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB26294.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; CM001743; KJB26294.1; -; Genomic_DNA.
DR RefSeq; XP_012476499.1; XM_012621045.1.
DR AlphaFoldDB; A0A0D2R2X6; -.
DR STRING; 29730.A0A0D2R2X6; -.
DR EnsemblPlants; KJB26294; KJB26294; B456_004G235800.
DR GeneID; 105792459; -.
DR Gramene; KJB26294; KJB26294; B456_004G235800.
DR KEGG; gra:105792459; -.
DR eggNOG; KOG0166; Eukaryota.
DR OMA; GGFHETQ; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000032304; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF58; IMPORTIN SUBUNIT ALPHA-4; 1.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 119..162
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 162..204
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 59578 MW; 737380625C3BCD02 CRC64;
MSLRPGSRTE VRKKSYKTGV DADEARRRRE DNLVEIRKNK REDNLLKKRR EGLLLQSQQP
LLDAVQNAAA IEKRLESIPL MVQGVWSEDP ASQLEATTQF RKLLSIERSP PIDEVIKAGV
VPRFVEFLGR QDVPQLQFEA AWALTNVASG TSEHTRVVIE HGAVPMFVQL LSSASDDVRE
QAVWALGNVA GDSPSCRDLV LGNGALMPLL AQLNERSKLS MLRNATWTLS NFCRGKPPTP
FEQVKPALPV LRELIYLNDE EVLTDACWAL SYLSDGPNDK IQAVIEAGVC PRLVELLGHP
SPTVLIPALR TVGNIVTGDD NQTQFVIDNK VLPHLYQLLV QNHKKSIKKE ACWTISNITA
GNKAQIQAVI EANIILPLVH LLQLAEFDIK KEAAWAISNA TSGGSHEQIQ FLVSQGCIKP
LCDLLICPDP RIVTVCLEGL ENILKVGEAD KEMGMNGGIN LYAQMIDECD GLDKIENLQT
HDNHEIYEKA VKILERYWAE EEEDEQNIQD GGNENQQGFN FGVNQQPSAP PGGFKFG
//
