ID A0A0D2U8Z3_CAPO3 Unreviewed; 1210 AA.
AC A0A0D2U8Z3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Guanine nucleotide exchange factor {ECO:0000313|EMBL:KJE91536.1};
GN ORFNames=CAOG_002664 {ECO:0000313|EMBL:KJE91536.1};
OS Capsaspora owczarzaki (strain ATCC 30864).
OC Eukaryota; Filasterea; Capsaspora.
OX NCBI_TaxID=595528 {ECO:0000313|EMBL:KJE91536.1, ECO:0000313|Proteomes:UP000008743};
RN [1] {ECO:0000313|Proteomes:UP000008743}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30864 {ECO:0000313|Proteomes:UP000008743};
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C.,
RA Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., White J., Yandava C., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Capsaspora owczarzaki ATCC 30864.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KE346362; KJE91536.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2U8Z3; -.
DR STRING; 595528.A0A0D2U8Z3; -.
DR EnsemblProtists; KJE91536; KJE91536; CAOG_002664.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; A0A0D2U8Z3; -.
DR PhylomeDB; A0A0D2U8Z3; -.
DR Proteomes; UP000008743; Unassembled WGS sequence.
DR GO; GO:0000786; C:nucleosome; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR002119; Histone_H2A.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00414; H2A; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000008743}.
FT DOMAIN 194..382
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 429..535
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 588..721
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 758..994
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 990..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1060
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 136161 MW; 7A4A5F1A542955A7 CRC64;
MANYDFSANA QKWEKLFIQA IRSVGHQVHP GLTIEEETLV YVDSLLYQVL SFLCTPAPRK
IQDVEDRVKA NFPEDLTQWA VREAQDALRK YKDNKKKSAQ ILSFPVEKVY QKLLKEISAT
VNIKAEYEVS VYINAVLEYV SADVLKLAGN YTDNCKRTSI TPKDVNVAIS ADRVLDQLFK
FKSDKPVPKK VVHSKEEAVR DMLAVETKYM RDVDMVVKIF LELFESAKDS DPSLFTERNI
VYIFCNIREI HDFEREFVYA LEEAREFNPK KPLVGAIFED MALEEKFEVY SEYAANFENS
RRELEAILRD PRVIAFLEAR KMKEAVMYVL PKLLFEPLYQ VFHYFDLLKI LLKCTETSDP
DHNSIRQAQI SLMNLEDELK RTCKDFLVKR NNTYLKHGKN SAVSEGIFKD IQMKIENWEG
SDLAIQCSDL YKEGLVQSKD AAGSKMLTTS KERYLIVFDN LILLCKPRGQ PSANCDFHVK
ERIKTSSLTV REIQDTDDMK FAIEITTSDG KRYPFGCKSP IEKAEWLEAL HTLAVRPTLE
KTLDKKIAEA EASDGPLLEL LNPGQYVFAQ QDSVSNILHE TEEGQTNGPP VIKGGSIYKL
VERLTYPSYA DPNYLTQFLI TYRSFCTPTD LLNLLIERYN VPEPVNVPQE QLLRFRKNYI
TPVRLRVFNV FRQWVDKHYY DFENNTDLLK RFLEFIKDSM SGDKKMDKAV KSLTRAVRQR
RETIENAKTI IFSDPPPPTE KGSAALDKIE DFDVLSLSPI EIARQLTLIE SDIYRTIKPS
ELVGQPWVKS DKEERSPNVL KMIHRFNAVS RWVATCVVDT ESLKERVDVI INFLEVLAEC
ERLNNFNGMM EILSGLQATS VYRLKFTWAE VPAKKRAILD DAASLLSRDG NFKKLRERLH
TVNPPCIPFF GMYLTDLTFI EDGTTDYLPT ANDAIKLINF TKRRRVASVI AEIALHQNLP
YNLAVVQLLQ DFCYHAVFIE EEEGFAKSLE IEPRNAEKAP DAPSGKPTRL RRSASTASMA
KDGRMQRASS QQDLNGFDSK RLSQTGGTIG KRTGRANSGQ TVLEDEEEAP APAPALPPKS
RPVSVMSVSP DSPGGDSGAA PPIPARNRRQ SEVGGSSPPV FGHGTPPSLP PKVGMPLTIG
SPSLSHGFGA GPNSPGPNSP GGGFNSNSLK NKAPPPLPPK AGVPGLSTSP SNSSPGVPPI
KSRPLPTPPS
//
