ID A0A0D2VV98_GOSRA Unreviewed; 681 AA.
AC A0A0D2VV98;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=NAD(P)-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B456_012G042300 {ECO:0000313|EMBL:KJB75445.1}, Gorai_004111
GN {ECO:0000313|EMBL:MBA0600917.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB75445.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB75445.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
RN [2] {ECO:0000313|EMBL:MBA0600917.1, ECO:0000313|Proteomes:UP000593578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8 {ECO:0000313|EMBL:MBA0600917.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:MBA0600917.1};
RX PubMed=30476109;
RA Grover C.E., Arick M.A. 2nd, Thrash A., Conover J.L., Sanders W.S.,
RA Peterson D.G., Frelichowski J.E., Scheffler J.A., Scheffler B.E.,
RA Wendel J.F.;
RT "Insights into the Evolution of the New World Diploid Cottons (Gossypium,
RT Subgenus Houzingenia) Based on Genome Sequencing.";
RL Genome Biol. Evol. 11:53-71(2019).
RN [3] {ECO:0000313|EMBL:MBA0600917.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=8 {ECO:0000313|EMBL:MBA0600917.1};
RC TISSUE=Leaf {ECO:0000313|EMBL:MBA0600917.1};
RA Grover C.E., Arick M.A. II, Thrash A., Conover J.L., Sanders W.S.,
RA Peterson D.G., Scheffler J.A., Scheffler B.E., Wendel J.F.;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; CM001751; KJB75445.1; -; Genomic_DNA.
DR EMBL; JABEZZ010000012; MBA0600917.1; -; Genomic_DNA.
DR RefSeq; XP_012459028.1; XM_012603574.1.
DR AlphaFoldDB; A0A0D2VV98; -.
DR STRING; 29730.A0A0D2VV98; -.
DR EnsemblPlants; KJB75445; KJB75445; B456_012G042300.
DR GeneID; 105779695; -.
DR Gramene; KJB75445; KJB75445; B456_012G042300.
DR KEGG; gra:105779695; -.
DR eggNOG; KOG0747; Eukaryota.
DR OMA; TIAWEHS; -.
DR OrthoDB; 5486426at2759; -.
DR Proteomes; UP000032304; Chromosome 12.
DR Proteomes; UP000593578; Unassembled WGS sequence.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:InterPro.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR43000:SF32; TRIFUNCTIONAL UDP-GLUCOSE 4,6-DEHYDRATASE_UDP-4-KETO-6-DEOXY-D-GLUCOSE 3,5-EPIMERASE_UDP-4-KETO-L-RHAMNOSE-REDUCTASE RHM1-LIKE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304}.
FT DOMAIN 11..316
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
FT DOMAIN 391..563
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 681 AA; 77354 MW; 0AF0F54FF30F9BAB CRC64;
MANKYTPKNI LITGAAGFIA SHVCNRLIRN YPDYKIVVLD KLDYCSSLKN LDRSRSSPNF
KFIKGDIASA DLVHFILQTE FIDTIMHFAA QTHVDNSFGN SFEFTKNNIY GTHVLLEACK
VTGQIKRFIH VSTDEVYGET DEDAVVGNHE ASQLLPTNPY SATKAGAEML VMAYGRSYGL
PVITTRGNNV YGTNQFPEKL IPKFILLAMN GKILPIHGDG SNVRSYLYCE DVAEAFEVIL
HRGEVGHVYN IGTKKERRVF DVARDICRLF NLDPESQIKF VENRPFNDQR YFLDDQKLKS
LGWYERTTWE EGLKKTMEWY VSNPDWWGDV SGALLPHPRM LMLPGIERQF NAPDSSNSGL
GSAPVTNKFN QSRMLVPSPK HNIPSQKPSL KFLIYGRTGW IGGLLGKLCE KQGIPFEYGK
GRLEQRSQLL DDIQTVKPTH VFNAAGVTGR PNVDWCETHK PETIRTNVVG TLTLADICRE
HDLLMINYAT GCIFEYDATH PLGTGVSFKE EDKPNFTGSF YSKTKAVVEE LLREFDNVCT
LRVRMPISSD LSNPRNFITK ITRYNKVVDI SNSMTILDEL LPVSIEMAKR NLRGIWNFTN
PGVVSHNEIL QMYKDYIDPN FNWVNFSLQE QAKVIVAPRS NNELDASKLK NEFPELLSIK
DSLIKYVFEP NRKTFAWELS N
//
