ID A0A0D8CRG3_9GAMM Unreviewed; 852 AA.
AC A0A0D8CRG3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=SG35_22585 {ECO:0000313|EMBL:KJE39148.1};
OS Thalassomonas actiniarum.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Thalassomonas.
OX NCBI_TaxID=485447 {ECO:0000313|EMBL:KJE39148.1};
RN [1] {ECO:0000313|EMBL:KJE39148.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A5K-106 {ECO:0000313|EMBL:KJE39148.1};
RA Olonade I., van Zyl L.J., Tuffin M.I.;
RT "Genome sequence of Japanese sea anemone isolate Thalassomonas
RT actiniarum.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJE39148.1}.
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DR EMBL; JYNI01000052; KJE39148.1; -; Genomic_DNA.
DR RefSeq; WP_044834742.1; NZ_CP059735.1.
DR AlphaFoldDB; A0A0D8CRG3; -.
DR STRING; 485447.SG35_22585; -.
DR PATRIC; fig|485447.4.peg.4974; -.
DR OrthoDB; 9802448at2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 689..705
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 615..622
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 852 AA; 94353 MW; 1349ADB143AB98EF CRC64;
MTTTDFSSHT PMMRQYLTIK AEFPHILVFY RMGDFYELFF DDAKKASDLL DISLTARGKS
GGNAIPMAGV PYHAVETYLA KLVQLGESVA LCEQIGDPAT SKGPVERKVV KVVTPGTVSD
EALLSDRQDN LIVAIAETAQ GFGLAYLDMT SGRFVLTEPR SSEQLQAELQ RLSPAELLYP
ESFSEMTLID HRKGLRRRPD WEYDLDTAVK LLNKQFGTKE LSGFGVSEQT RGLAAAGCLF
QYVKDSQRTA LPHIRAIISE SSATGVVLDA ATRRNLELTM NLSGGLENTL ASILDKSATP
MGSRLLKRWL HFPLRELNTL SNRQNAISDI LAHDLQQELF DLLKPLGDVE RIVSRIALRS
ARPRDFARLR NALQQLDELQ QVLAVSPKDY LLQLARDTKP LPEIQGLLEQ AIIDNPPVLI
RDGGVIAPGY HQELDRLRDL SDGATSLLSE IEEREKARTG IHSLKVGYNK VHGFFIEVGR
ASAGDVPPEY IRRQTLKNNE RYITEELKQH EETVLSAQSK FLALEKRLYD ELFDKVLPEL
AQLQQLAQGL AELDVLNTFA ERAETLNYVK PSLSNTPGIE IEAGRHPVVE QMTEDAFIAN
PVALNQDRKM LIITGPNMGG KSTYMRQTAL IVLLAHIGCY VPASTAKIGM VDRIFTRIGA
SDDLASGRST FMVEMTETAN ILHNATDKSL VLLDEIGRGT STYDGLSLAW ACAEMLANKT
RAFTLFASHY FELTLLAEQI PSLANVHLDA VEHNDNIIFM HAVQEGAASK SFGLQVAQLA
GVPKTVIHRA KQRLAELENQ QAPSILPASE ASFEQLPLMD NHPVVDVLAA TDINDLSPRQ
ALDLLFNLKE QL
//
