ID A0A0D8HGB4_9ACTN Unreviewed; 463 AA.
AC A0A0D8HGB4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Metalloprotease TldD {ECO:0000313|EMBL:KJF17025.1};
DE EC=3.4.-.- {ECO:0000313|EMBL:KJF17025.1};
GN Name=tldD {ECO:0000313|EMBL:KJF17025.1};
GN ORFNames=AXFE_20960 {ECO:0000313|EMBL:KJF17025.1};
OS Acidithrix ferrooxidans.
OC Bacteria; Actinomycetota; Acidimicrobiia; Acidimicrobiales;
OC Acidimicrobiaceae; Acidithrix.
OX NCBI_TaxID=1280514 {ECO:0000313|EMBL:KJF17025.1, ECO:0000313|Proteomes:UP000032360};
RN [1] {ECO:0000313|EMBL:KJF17025.1, ECO:0000313|Proteomes:UP000032360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Py-F3 {ECO:0000313|EMBL:KJF17025.1,
RC ECO:0000313|Proteomes:UP000032360};
RA Poehlein A., Eisen S., Schloemann M., Johnson B.D., Daniel R., Muehling M.;
RT "Draft genome of the acidophilic iron oxidizer Acidithrix ferrooxidans
RT strain Py-F3.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJF17025.1}.
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DR EMBL; JXYS01000067; KJF17025.1; -; Genomic_DNA.
DR RefSeq; WP_052605731.1; NZ_JXYS01000067.1.
DR AlphaFoldDB; A0A0D8HGB4; -.
DR STRING; 1280514.AXFE_20960; -.
DR PATRIC; fig|1280514.3.peg.2748; -.
DR OrthoDB; 9803213at2; -.
DR Proteomes; UP000032360; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KJF17025.1};
KW Metalloprotease {ECO:0000313|EMBL:KJF17025.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:KJF17025.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032360}.
FT DOMAIN 22..86
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 117..220
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 227..459
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 463 AA; 49308 MW; EBA9426B76F6AF32 CRC64;
MIESNLVEKV IRSALSRGGD FAEIFVEEKT TFSASLDDAI VEELSSGTAR GAGIRVRYGD
TTGFAHTADL SENGLLRAAQ AASSLAQNSS KSRQIMALQE RVFSPIDPLK NLPMTIAKDR
KIELLKHLND AARSAGSAIR QVGASYSDSL RRFLVANSDG VFVEEEQIRT RISISAIALG
DTGMQGGYET VAMTKGFEIF QDLDIEQMAL KAANRAILKL SARPAPSGQV PVVLNGLGGG
VLFHEACGHG LEADHVLKES SVYAGKIGRS VASPLVTLLD DGTVTDQWGT FHHDDEGHIS
SKNTLIQDGV LVDYMWDQTQ GDRTKRDSSG NGRRQSYAHL PMVRMTNTYL MPGESTPQEI
IADTEYGIYV SQLGGGQVNT ATGDFVFGMT EAYLIEDGRI TAPLREANLI GNGPEVLANI
DAVANDFSIV PGTCGKDGQS VPVGCGQPTL RIKAVTVGGT AGA
//
