ID A0A0D8HLN4_9ACTN Unreviewed; 395 AA.
AC A0A0D8HLN4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Putative acyltransferase {ECO:0000313|EMBL:KJF18667.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:KJF18667.1};
GN Name=fadA1 {ECO:0000313|EMBL:KJF18667.1};
GN ORFNames=AXFE_04530 {ECO:0000313|EMBL:KJF18667.1};
OS Acidithrix ferrooxidans.
OC Bacteria; Actinomycetota; Acidimicrobiia; Acidimicrobiales;
OC Acidimicrobiaceae; Acidithrix.
OX NCBI_TaxID=1280514 {ECO:0000313|EMBL:KJF18667.1, ECO:0000313|Proteomes:UP000032360};
RN [1] {ECO:0000313|EMBL:KJF18667.1, ECO:0000313|Proteomes:UP000032360}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Py-F3 {ECO:0000313|EMBL:KJF18667.1,
RC ECO:0000313|Proteomes:UP000032360};
RA Poehlein A., Eisen S., Schloemann M., Johnson B.D., Daniel R., Muehling M.;
RT "Draft genome of the acidophilic iron oxidizer Acidithrix ferrooxidans
RT strain Py-F3.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJF18667.1}.
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DR EMBL; JXYS01000010; KJF18667.1; -; Genomic_DNA.
DR RefSeq; WP_052604256.1; NZ_JXYS01000010.1.
DR AlphaFoldDB; A0A0D8HLN4; -.
DR STRING; 1280514.AXFE_04530; -.
DR PATRIC; fig|1280514.3.peg.628; -.
DR OrthoDB; 3204099at2; -.
DR Proteomes; UP000032360; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KJF18667.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032360};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KJF18667.1}.
FT DOMAIN 5..263
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 272..391
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 91
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 349
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 379
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 395 AA; 41936 MW; 3E4798AF8D1531D6 CRC64;
MTRAAVVDVV RTPFAKGRES GSLAGVHPVD LLARCLTAIV ERSGIAAEYI DDVIIGCSLP
VAEQSGNIAR NAVLAAGYPE TVPAVSIDRK CGSFQQSMHF AAQGIISGAY DVAVAGGVEV
MGLVPMKANR MGKDEKGPSF HRRYPAGLIS QGVSAELIAS RYNILRQQLD EYSLRSHQLA
DGAMKTTSKI ASMVAIENSG RIVESDDGIR PNSTFEALSS LRPAFYSHEM AERFPEIEEW
RITAGNSSQI SDGAGAGLIV SEDFARENGL SIKGYLSNFS VVGDDPIMML TGVIPATRKL
LERSGLEIMD IDLFEVNEAF ASVVLAYAKE LEVPLDRLNV SGGAIAYGHP VGASGVRLFT
QIFDDLAQRG GGRGVVTMCE SGGMANATLV EVTDG
//
