ID A0A0D8I8P3_9CLOT Unreviewed; 313 AA.
AC A0A0D8I8P3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=D-3-phosphoglycerate dehydrogenase SerA {ECO:0000313|EMBL:AKL96262.1};
DE EC=1.1.1.95 {ECO:0000313|EMBL:AKL96262.1};
DE SubName: Full=Dihydrofolate reductase {ECO:0000313|EMBL:KJF26665.1};
GN Name=serA1 {ECO:0000313|EMBL:AKL96262.1};
GN ORFNames=CACET_c28170 {ECO:0000313|EMBL:AKL96262.1}, TZ02_12435
GN {ECO:0000313|EMBL:KJF26665.1};
OS Clostridium aceticum.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=84022 {ECO:0000313|EMBL:AKL96262.1, ECO:0000313|Proteomes:UP000035704};
RN [1] {ECO:0000313|EMBL:AKL96262.1, ECO:0000313|Proteomes:UP000035704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1496 {ECO:0000313|EMBL:AKL96262.1,
RC ECO:0000313|Proteomes:UP000035704};
RA Poehlein A., Schiel-Bengelsdorf B., Gottschalk G., Duerre P., Daniel R.;
RT "Genome sequence of Clostridium aceticum DSM 1496.";
RL Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KJF26665.1, ECO:0000313|Proteomes:UP000032372}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1496 {ECO:0000313|EMBL:KJF26665.1,
RC ECO:0000313|Proteomes:UP000032372};
RA Song Y., Hwang S., Cho B.-K.;
RT "Draft genome sequence of Clostridium aceticum DSM 1496, a potential
RT butanol broducer through syngas fermentation.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; CP009687; AKL96262.1; -; Genomic_DNA.
DR EMBL; JYHU01000013; KJF26665.1; -; Genomic_DNA.
DR RefSeq; WP_044825278.1; NZ_JYHU01000013.1.
DR AlphaFoldDB; A0A0D8I8P3; -.
DR STRING; 84022.CACET_c28170; -.
DR KEGG; cace:CACET_c28170; -.
DR PATRIC; fig|84022.5.peg.753; -.
DR OrthoDB; 9805416at2; -.
DR Proteomes; UP000032372; Unassembled WGS sequence.
DR Proteomes; UP000035704; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd12155; PGDH_1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43333; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43333:SF1; 2-HACID_DH_C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000035704}.
FT DOMAIN 10..307
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 105..275
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 313 AA; 36485 MW; C685030C33F1B472 CRC64;
MKVLFTYDYG KEKMDAIEKL GYDIILQSEK GIVYTEAMQD VEALICYSPF HTLDIAKMKK
LKWIQLSSIG IDQVPKDIAR KNKIIVTNNK GGYSIPIGEW VVLKILEIYK KSSKLYRQQQ
QKRWEMDTSL LELYRKRIGF IGTGSIAIES AKRLQGFEAH ILGVNTKGRK VEYFDKCYPI
HQLEEVLKTC DVVVVTVPYT EETHHLINKV KLEMMKKEAV LINVSRGSII DEKALIQHLQ
KGNLLGVALD VFEEEPLSQE NPLWEMERVL VTPHNCWISE MRNERRFRII YENMKKFKEE
LPLINQVDIN KGY
//
