ID A0A0D8JWG3_COCIM Unreviewed; 557 AA.
AC A0A0D8JWG3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 28-JUN-2023, entry version 34.
DE RecName: Full=Peptidase A1 domain-containing protein {ECO:0000259|PROSITE:PS51767};
GN ORFNames=CIMG_11804 {ECO:0000313|EMBL:KJF60613.1};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:KJF60613.1, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704912; KJF60613.1; -; Genomic_DNA.
DR RefSeq; XP_012214122.1; XM_012358699.1.
DR AlphaFoldDB; A0A0D8JWG3; -.
DR GeneID; 24163889; -.
DR KEGG; cim:CIMG_11804; -.
DR VEuPathDB; FungiDB:CIMG_11804; -.
DR InParanoid; A0A0D8JWG3; -.
DR OMA; YSFGMHI; -.
DR OrthoDB; 1947353at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd21699; JMTM_APP_like; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR Pfam; PF00026; Asp; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..557
FT /note="Peptidase A1 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002331679"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..409
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 457..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 535..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 557 AA; 60943 MW; 64C7982A67DE84B2 CRC64;
MNLTPLLWIA CLRVGLVFGA ANFAVPWSST KYGPDGPWQA VKVSVGGVDE TLRYNLQSTD
LDLYPGSRYA SQILVPEACE PHERDGICGK GGEWDITAKS TMAISWPGSY ENPPMNQTSG
ECDFNIQGLT INDITVWNTS LVAVDNVTIT TAKGITYGPP VGLLALGGDK TVQEFTTSSS
RTGALRTYIY PGGLYDQDII PSYSYTLQIG SAAHDYVGSL VFGGYDKGRI IGPYTTSAET
TFRLLDIGIG VQTGGSPFPF KKKDNLLVTG TSSDDHVTVY PDATLPYMFL PAQTCEEIVK
HLPVEWDSEL SYYLWKTDDP LYKSITSSPA YLSFTFPPAS GAEDNVVIKV PFALLNLTLE
SPITESPKIY FPCYPFSLTE NDDNYHLGRA FLQAAFLGRN WLSKMTWLAQ APGPGSQREG
LGKQLEDIPD RANTLSYFDP EGQFQRSWEN YWQPLERDLS PQSPESTPGS PTDDKDDSSL
GTGAKVGIAI GAIVGALIIL GAIFYFKRRS KRPVMGPSHT FTPVEQGKEQ PIQYYGGPAV
EIQGSEPTRY EMDAGTR
//
