ID A0A0D8XAZ8_DICVI Unreviewed; 1383 AA.
AC A0A0D8XAZ8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=AMP-binding enzyme {ECO:0000313|EMBL:KJH40819.1};
GN ORFNames=DICVIV_13220 {ECO:0000313|EMBL:KJH40819.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH40819.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH40819.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH40819.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN717005; KJH40819.1; -; Genomic_DNA.
DR STRING; 29172.A0A0D8XAZ8; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0008250; C:oligosaccharyltransferase complex; IEA:InterPro.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0006487; P:protein N-linked glycosylation; IEA:InterPro.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR034704; Ribosomal_bL28/bL31-like_sf.
DR InterPro; IPR008814; Swp1.
DR PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43201:SF8; FATTY ACID COA SYNTHETASE FAMILY; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF05817; Ribophorin_II; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF143800; L28p-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 979..1271
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 1322..1381
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 1383 AA; 155457 MW; FE5F34BD5D9D1544 CRC64;
MSFQQTNDAL AQQQYHIGNM IIFCFFVLAI PPIYASVSLN EYWNDDDTVR LSKVLEGVLR
TKKDNIASLH YATSGIKLLN VAPSAPLAST VCEIAKKADL NILEALYHAS AIAGDLPDCT
LSDIAVAQNT IEKVLKESHL SGERITQALR SADRLGIKVD KAAFDKLLTA AMKDGSPSNL
AWIFNAAALL DKSTATKYFN KIKYLVSQAD EVDGRYLQFD GGLLTTANAV HGIMSLAEQQ
GKVPSITKPI KITICNVFGL PVDISGVRVD ITPSEANTPV VSNLKLIPVE RSSKLYMISS
DKIPQAVGFY DVAVKIDSKD NRLVGLTGSS VVFKLSDDVK VDDLRVGVLE KDDVVTGMST
ASVAPFSKLG KILTADHTKR LFVSFSVKWK SNGDMVQPNQ AFILFKHTDG SEVFYTADLQ
NDGKYVIDVN LNKAHKDFEG LSGKYTAYLI IGDPLIKTPM NWPFADFMLA VPPAPVRVIP
KSQQVIYNAL PEIKHVFRQP EKRPAVVVSD TFTVICLSPL LLLIILWYRI GINFGNIPVS
LWTLFFHGGL TALFALYFVF WLRLNMFETL KYLAVIGAFT YLSGNRVLRA VAHKRNIANS
DAGVKEIIRS VEFTAIVSLA PWGLCKRRNE SSHGVLTKPH VYAASVESGY TTMSLTKNLI
SLTSVGPRPI ITWDKAERIR RHEEIWANPN SVVHRLPEHY CKRYWDNLLR EATPVHYRPP
ASRLYWDPKR MVEVEAENYP LYVIFPPEAD DGLWGGEGVV KGWKESRPFT KKKVLPRHWV
PHLYFPTLKT SVLYSEILDR HMKIVVTERA LRLIDQHFGL DYYILRTPLI DLASKLGNRL
KREMLLTLAK GEYYANDKER HNYIKNKYAE FVIPVEEADW IGLDLNEASR KQQEIEDRQV
VEPLKFNFKT DDVVGDMKEN WCLDYVLERT SLQTKNTHQN QRRFMFLRRF VLVIRTSIRQ
IASADQNILY RAGLENDPKQ KGDRVLCRTS KTLDAVALYM ACLQIGAIYI PVNISYTRRE
TEHYVEDSTP KLMVTCNEAE DSVFHPKIIN IVSESKLSAE SNRCKAQLEI EIVENNDVAC
ICYTSGTTGL PKGVMLTHNS LSTNAEALVD AWRFTKYDKQ LHMLPFYHVH GMFISLNCSL
FSHSTVIFKE KFSVDSCLKW LPSTTVMMGV PTYYSRLSSS PNFNRKLLPH LRLFVCGSAP
LSTPLWEEFK SRTGHAILER YGMTEAQVIC SNPYDDRRPG LVGKPIAGTE LRINKEGGIE
IRSSSLFAGY WNNPEKTADD FTSDKYFVTG DVGSVDEDGY LRILGRTKDL VITGGFNVYP
KEIEDCIDRL PGVEESAIIG VPHSDLGEAV VAVVGGKIPT NDKIKEQEII AALKNVLVSY
KIL
//
