ID A0A0D8XL69_DICVI Unreviewed; 993 AA.
AC A0A0D8XL69;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Leucine Rich repeat-containing domain protein {ECO:0000313|EMBL:KJH45275.1};
GN ORFNames=DICVIV_08691 {ECO:0000313|EMBL:KJH45275.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH45275.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH45275.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH45275.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KN716417; KJH45275.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XL69; -.
DR STRING; 29172.A0A0D8XL69; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF13676; TIR_2; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 768..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 826..963
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 993 AA; 111417 MW; 0CB1B22C1CBACF11 CRC64;
MGLTCATLLD GLSSNCLENL SIAQVHVLNV SSNWISTLSF ASSCVANQLI IVDFSYNRIE
NLQQDLHTLP FIRQLSLSNN RLSTLYKKSL YKCSLLQQLE LNNNALDVIE DLPETLIHIN
LANNHLTIIP PPVALLPHLV SLNLSHNSIN ENSPTACVSD VLESIDLSWN HIKVLPTRLF
PYSVSSVTHL HLESNMIADL EPLEFMNYTR LQTLNLASNK IRHLRDGVFA GIYEFSSLLL
SNNSIETVGP EVFADLSIGV VDLSYNELAE IPMAIGRLFS LKKINLSHNN IKWAFGFYFF
FHGFQFHHFL IFRLDFNYAD SGLESLSDTL SQASAVRLLD VSRNSLDFLQ WNELPPRLEH
LIADSNVISL LGAASRSKLV ILNDITIKCI WKAASTFSMK TAMRSLDLSD NRLSQLRMES
LVTNGVNSID LNLKGNSLKC GCELHWMTMT GTLKRRVNVI DKSRTQCTHT INGNVISLDE
VEAKDLLCDY TQVCEPECVC CQFGNCDCKA VCPLGCSCFH DASFETNIVR CENLTEQQMQ
EFTPSAVPMS ATHVYISGLK LPILRSHSFL GRPRLEFLHI NASGIRGIQS KAFNTLPNLK
LLDLSDNRLV RLSGDEFHKT TSVSHLFLNG NRLKSVEKGL TDKLPSLIMM TLHNNELTDI
SPALASSHVD SLSLSGNAFR CDCSPRFSAP TWIHQNRAKV VDIAQIYCVE NITESFRNND
TTVLSAYRPN IGHDIFTMPM DEFLRDFNLS ICVPLSSGFF GQEPQNSILT IVFLASCLFL
LCAMVFLGIS VVRKAQNDMS QRRYKASSSL NCSSTPRSSP LPVPLLNFDA FVSYSKKDEK
MVLEQLCRPL EDEEYTLCLL HRDGPTYHSR LHAISDELIS QMEASQCLVI ILTKNFLESE
WKTLQIKTSH QLFAKNRSKR IIAILGDGVD QNLLDEELGQ ILRKNTCIRQ RDHLFWQLLH
NAMPTQLSSI PSSGDTNSQI YSDMYGIVPS AVI
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