ID A0A0D8XMK6_DICVI Unreviewed; 1525 AA.
AC A0A0D8XMK6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Putative arginine--tRNA ligase {ECO:0000313|EMBL:KJH45858.1};
GN ORFNames=DICVIV_08086 {ECO:0000313|EMBL:KJH45858.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH45858.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH45858.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH45858.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
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DR EMBL; KN716382; KJH45858.1; -; Genomic_DNA.
DR STRING; 29172.A0A0D8XMK6; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd17678; RUN2_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR035684; ArgRS_core.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR PANTHER; PTHR46070:SF1; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF05746; DALR_1; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03151; TPT; 1.
DR Pfam; PF00750; tRNA-synt_1d; 2.
DR SMART; SM00836; DALR_1; 1.
DR SMART; SM00593; RUN; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50826; RUN; 2.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:KJH45858.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 816..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 882..904
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 934..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 958..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1009
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1029..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1077
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1083..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 174..469
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 654..803
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 347..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..367
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1525 AA; 172177 MW; BEEB7F142187EB64 CRC64;
MFTSLIDAKI LSQWETPDDN LVIFDTRIAK MREKFGLSMV RTPTYESTPS FGDSEELISK
REEMLDYVVP GPHELAGAVS MNYNGVWPEQ INTALLEGAS ISVIGRPNST YGSTGLVGDS
PDLIAKQQLK FVDQLLYETK GTVICLGKTK RMLVDKMGKE ALQLGHFDAG INGVEENTLV
ASFCDLLERI WAHGLTKKQG KSSLWSFVLQ HQDLEKTCLS TKALSSSMLT PGDGRRHTIK
RTPSLSYCEV PSPVILQPTN ENDFACALSE IVETIQREFG KSDDDNVPVW SRSILRAANF
FADKLTTTPK DEIHGVPFAT SAKRHSSTLL KNSSSVSDFS SPNWNGEIRR SAESSDSPRR
RSQSRPRSPE TGARVLLAPL PTHIAYDLKN VLRMTEIKTD IGYARAFVRL ALERKLLHKH
LATLLANNHL LSELYKPYAF VRCEDEREQF LYHILSLNAA QFRCFTNTFT KTKMDYQVVI
VTGGWRGSLP AVWVMHKNLG VLSTLRIGHS PGTEKPPNWY LEYIIVRNEI TGQMYRFPCG
RWFGQSAEDR RWFGNSCDVS LERLLVAEPI CGNDSADLTF GALPNSPVRG TRRGRVSSRS
QTPQRDRSPS QSRTYSSTSS SKARVTEIQQ VLGESVNSLV KYFYSEKHTK SELAYLLCGE
HGLINAIEQA FQFGRHTSVW LFRQPSPWDY IEKVCSWLMD VLRRRDTKWT PEQCELVTHT
LKLVRKISNR TALGKDAKFH VFILLMIRDH ILSGFLQVMA WTPITAQLYD EVSFLRAPVH
LTYLSRLLDS LNEFNFSLDP SLTYGVMGNS ILLKRFSAAF FYGVTSIIVV FVNKILLTNF
RFPSFLVVGF GQMVATVIVL FSARALHLVS FPSFDYSIPR KIMPLPLFFV VNLVSGLGGT
QLINLPMFTV LRRFSILMTM VLEYYILGVS ATRAVRISVC LMIAGSIIAA LFDLTFDLWG
YILIGVNDIC TAALGVYTKQ KLEAKELGKY GLMFYNSLFM LLPTVLLTFY TGDMNRALNF
MLSSQMSPSI WACFFVSCVC GFILNYSLVL CTHFNSALTT TCVGPIKNII VTYAGMFSSG
DYIFHWTNFI GINISVMGSI LYTYATFRKK STDQRILTVV PSSKLESQIK NLLRKTSFSQ
VHRAVGNQVV SLNYLGDWGT QFALIATYWP KVRPSDSFWD SCSDVDKIRA ITDCYIVANK
KRKLDEEFQV EVRKNFAEME NGIIKWQYES ENVIAARRLV ADLIKNNTVR RTVNGLWIVD
IPNDDLNEEI ASILNRDKIY HADRYLYVVD RAQRKHFEAL RVILTKIGRD DLALKVEHIP
YGRVKGLSTR LGRTEIVEEI ISRGKELALR FMKNSKTFKL SSEEEEEVAH KLSLSTVIFN
EVKRAKSAEY EFSFKNAFDL DHNNALSLQV RHSRLCSIEA KNHELLPLLD KCDSIPEETP
DFSKLAVHLS QFSTVIHAAV EQSESCHLVV YLLELSHHIG KVTSQARIKG QPVEVAVPRL
LLLSASRAVL NEGMSLLGAS PVTAM
//
