ID A0A0D8XWG6_DICVI Unreviewed; 812 AA.
AC A0A0D8XWG6;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=COP9 signalosome complex subunit 2 {ECO:0000256|ARBA:ARBA00014879};
GN ORFNames=DICVIV_05731 {ECO:0000313|EMBL:KJH48162.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH48162.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH48162.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH48162.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CSN2 family.
CC {ECO:0000256|ARBA:ARBA00009318}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00880}.
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DR EMBL; KN716277; KJH48162.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D8XWG6; -.
DR STRING; 29172.A0A0D8XWG6; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000123; C:histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 1.25.40.570; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR015418; Eaf6.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10678; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR PANTHER; PTHR10678:SF3; COP9 SIGNALOSOME COMPLEX SUBUNIT 2; 1.
DR Pfam; PF09340; NuA4; 1.
DR Pfam; PF01399; PCI; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR SMART; SM00753; PAM; 1.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053766}.
FT DOMAIN 254..416
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT DOMAIN 596..801
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 93410 MW; 7EF120D582D6FD9B CRC64;
MSDELMDDDE DYGFEYEDDS GSEPDVDLEN QYYTAKGLKS EGKIAEAIAN FEKVLNLEQE
MGEWGFKALK QMVKITFNSN QFEAMLQYYQ QLLKYIKTAV TKNYSEKSIN AILDYISTSK
QMDLLQKFYE TTLDALKDAR NERLWFKTNT KLGKLYFDMH EFHKLEKILK QLKSSCKTEQ
GEEDQKKGTQ LLEIYALEIQ MYTEQKNNKA LKKLYEQAQQ AIQSKSAIPH PLILGVIREC
GGKMHLREGQ FDRAHTDFFE AFKNYDESGS PRRITCLKYL VLANMLIRSD INPFDSQEAK
PFKNEQEIVA MTAMVAAYQE NDIDEFQRIL EHNRESIMQD PFIREHIEEL LTNIRTQVLL
RLIKPYTRIR LQYLSQKLRI TIAEVKRLLV DTILDEGLPA RIDEIDNILF VKPCGPQADS
SLSITAMNGW IEQLDKVLVA ITTRISFHVL QEKITCSYTG AYLCTSTNFI LNASLSNLFV
AYYCLQMSKD HDLKRELNEL IKKRAEIAET LEALENQIYN FEGSYLEETA EYGNVIKGWD
RYALAMPPSK SGVKLEKKSL SRKVDKDADR LFSYSSITSP AAIKHAQQPP PSITSSGAPL
TPTLMRNDSI DDEAVKICDF EGKYRDPHNP IRKLRQLCVQ ATVYCNKRAV GYSVMTSYKP
PPEEGDRSRS RLIQSWGEWL TLPVRYCDLS RDASLHFSVW ELTSGSELQS LFCHEQPKVS
FVCAPTPLPK RLVAQSSLPL FSKRGVFKSG TLDIQMELSE ELDPLHRCVE KWKTSDANDN
HLNELLKQCA AVPQFFPLSK RTIVPDVDFL WT
//