ID A0A0D8XX81_DICVI Unreviewed; 1970 AA.
AC A0A0D8XX81;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN ORFNames=DICVIV_04618 {ECO:0000313|EMBL:KJH49238.1};
OS Dictyocaulus viviparus (Bovine lungworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH49238.1, ECO:0000313|Proteomes:UP000053766};
RN [1] {ECO:0000313|EMBL:KJH49238.1, ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH49238.1,
RC ECO:0000313|Proteomes:UP000053766};
RA Mitreva M.;
RT "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000053766}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX PubMed=26856411; DOI=10.1038/srep20316;
RA McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA Sternberg P.W., Gasser R.B., Mitreva M.;
RT "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT lungworm biology and support future intervention.";
RL Sci. Rep. 6:20316-20316(2016).
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|RuleBase:RU368044}.
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DR EMBL; KN716241; KJH49238.1; -; Genomic_DNA.
DR STRING; 29172.A0A0D8XX81; -.
DR Proteomes; UP000053766; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 2.80.10.50; -; 3.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 2.
DR Pfam; PF02815; MIR; 2.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 2.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 3.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000053766};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|RuleBase:RU368044}.
FT DOMAIN 118..172
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 279..339
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
SQ SEQUENCE 1970 AA; 227160 MW; 0836609D18659A7E CRC64;
MNADIGNISL LHFGDIISLY TEESADLRGF LSTLGLVDDR CIVELRDGRP ESPPKKFRDC
LFKVCPVNRY AAQKQLWTEQ KRFISGESTF DSDMMNKLCI AAEKEKEQNE LEFRKTLGNV
IQYGTTVQLL HMKSDKYITV QKNTPAKCER NAMKVYLDRA GNEGSWFIIE PAYKHYVIGD
SVRKLVIHLL SADEHEPDAF NIQAVYDVKR LRQPVAAGNK ISLIPYSVNN HSSSGHVKHQ
LHLSHYVLKD HQTAVEVNCL NECTEWQVFM FLLFNENQQD IVKSGDVVRL FHADQQTFLT
LDVVPNTSPP KDVVFLRMTN RPSAADATSS RALWEVQVVQ KDAYRGGAAS WRECYRFKHL
ATDMYLTAVQ TVASVKSSTN DRRAYFTQIK ARAEHLPPSS DMLYDEETPD VCSFGIYFLM
PITSDFPEAD KRLLFSLDPG TMPKQLPHSF IHRYTVSITR IPDFFFQNKD VPCKSYVRLQ
HEATGMWVHA TNPNDKYNLY YSSKTEKGWV RVICANSRVD KETFALLPVH PNEVHSFIIP
LPVTIQLLTE CIYFVTNTKN HMRDPLQIND FVPSRDRQKL LREQEVLDQV FLLLKAPFMP
RQGITEIGPL LSSPSDLSEG RNEIFKTMFQ LCYSLLRYSQ TNYRKNQEFL AEKFGQIQEQ
IGYDLLAEDT MTAVLHNNPK LLEKYVKTPH VERFIELVRN NRLGKFLDYL ADLCVCRGEA
NKKIQELICN SVLSTKHRDI LMDTKMVDGE VYIGWMDQKL RSLVELADGS KNIKTEDAEF
LDYYRHQLDL LAQMCQEQQY LAIDPPPERK LLNLSQQLPA HLVLRCVSDG RLPCDVRASF
ARLMLHLHVV RGSPLCAIRH ARLWTDIPVE VKLQSYKITS LEGYSDGGRS RVGDQFATDV
LNTVENYLHS LRHNRPSGPL LKDDATSIAK NKLTHEMVTL AKALAQFGYY TFDNLLKLTE
NLLNIVDNSP QNLQTARTVS QGMSMIQRVT RSMTLGGKLG DGPMMKNSEK NAIDDNIQAK
ESRHLLLRTK LTVAEILQFV MDVRRDYRIT MALSWFKENF PCNEDGVLKQ TASINERMAH
ELYETIYQSS GHELHLDRGD GQLLLAILMQ VQLLVSSDDV ENYRQVDRDL FILKNLTEKS
ELWVRSERHH SIDAKDHERD DKITKSDFEE HSLITSKGFT SDDILKAVVA TIDEHYPNLR
KESLRLLNQK TLECMKSLLD IFKTLFVRKE DGFLKQILVR LKKLCYKNDR PEIMNQQLLK
NMRVYEVVLE FLSIPYDKED WNILNYLQKN DTEMPRLITL SHEFLRSFCR GNKENQIRLH
RYISIEKDAK EGTLRVETVG IVLFIFLFIV FHTVEEAATL VAIFRNNREL AANVSEDLIA
HIVNLIEHKV SEYLLVVRML KVIAIKPTRN AIFLELLQSL VCIHDKEIEP TQEKVASEIC
AASDEVRALY VDNASFEQLE QMMQQAPQYL DNTHPLKYHI ELSDEFYIQV TCDVHTWKKR
KHRVEMRIRD PDGSYSSSCH VTILPNRGKR EVMSSTFRLL AMCTRGKNGS IELKCASEIP
MDHIVRVVTS PFCLIEVKTA YFQFLLHCYI DTDAEMKDAY KPEYVDLLLQ NMLLDVQKLQ
HELTVSSSNC AILEQYVCVT ATEMLLKFFE KTYSEQAKAH KKMFTALLQN LCVLHAGSLK
RSQSPKHWYR IDQCIKRLRR WAEENKIALP ASIVLPPFTS APSVKQRWQC AANSARFIGQ
RTLTMRNRTN SLVMPGYNNN HHVTEKVANV VTCYHIDVYL LRLIQHCKTL MQKKQDNLCT
RVLQTLYRMC NSTKQSLSEQ GEQLRLKLLQ RYFGSRGNLE QNANNDTLAG NNSSGNQERK
LEIKLEERSL YDIQCRLNDA GASDLVIDII TDEPSQEIFL KAIQLAKAIL LDGNDKVQQS
FYDRLKKKDP HELFFKAISS RIQAAQNRLK SDMMSCNENR PKGVDEHSQP
//
