ID   A0A0D8Y7E2_DICVI        Unreviewed;       459 AA.
AC   A0A0D8Y7E2;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=OTU-like cysteine protease {ECO:0000313|EMBL:KJH50516.1};
GN   ORFNames=DICVIV_03366 {ECO:0000313|EMBL:KJH50516.1};
OS   Dictyocaulus viviparus (Bovine lungworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae; Dictyocaulus.
OX   NCBI_TaxID=29172 {ECO:0000313|EMBL:KJH50516.1, ECO:0000313|Proteomes:UP000053766};
RN   [1] {ECO:0000313|EMBL:KJH50516.1, ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|EMBL:KJH50516.1,
RC   ECO:0000313|Proteomes:UP000053766};
RA   Mitreva M.;
RT   "Draft genome of the bovine lungworm Dictyocaulus viviparus.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000053766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HannoverDv2000 {ECO:0000313|Proteomes:UP000053766};
RX   PubMed=26856411; DOI=10.1038/srep20316;
RA   McNulty S.N., Strube C., Rosa B.A., Martin J.C., Tyagi R., Choi Y.J.,
RA   Wang Q., Hallsworth Pepin K., Zhang X., Ozersky P., Wilson R.K.,
RA   Sternberg P.W., Gasser R.B., Mitreva M.;
RT   "Dictyocaulus viviparus genome, variome and transcriptome elucidate
RT   lungworm biology and support future intervention.";
RL   Sci. Rep. 6:20316-20316(2016).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KN716204; KJH50516.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D8Y7E2; -.
DR   STRING; 29172.A0A0D8Y7E2; -.
DR   Proteomes; UP000053766; Unassembled WGS sequence.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd22755; OTU_CeDUB-like; 1.
DR   CDD; cd02257; Peptidase_C19; 1.
DR   Gene3D; 3.90.70.80; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   PANTHER; PTHR12419; OTU DOMAIN CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12419:SF7; OTU DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 2.
DR   PROSITE; PS50802; OTU; 1.
DR   PROSITE; PS00973; USP_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:KJH50516.1};
KW   Protease {ECO:0000313|EMBL:KJH50516.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053766}.
FT   DOMAIN          234..406
FT                   /note="OTU"
FT                   /evidence="ECO:0000259|PROSITE:PS50802"
SQ   SEQUENCE   459 AA;  51908 MW;  861B3F59492504F9 CRC64;
     MLPEGERNGY STELWSTWYG GPSHEVKQLG VVYVALTACS LSYPEKENVA FSSMSALCTA
     VEGGVTKQTG GYVKESSFEE KCEIVEGSRE CREYEDPNTT ELVDNQLDCT NVTDTEDISR
     TIFSENGSND VKAVVSSEHS KHCDNNGIYA RQITEPLRPL NTSAPSTRLP QDVGVESVAV
     VGEHEEQITL FFRPVQEELQ KKWCLRFGLQ YVGTPDLRKH TFGRELEFSL RDTPQSCEVR
     GDGNCLFRTL CWWITGGSEI HHFLLREKLI SFMSKYRSKF TSFLQSQQDM DNHLLRMSED
     GEWGTQVELA AAACWLGVNI YTFLEGKWLK YRPLFRWSND GSAPARRSLR SRKEKDLIKV
     SLYACVVDSA YLSLITEPPY VFNSADGPVY SLSAVICHHG DSLLSGHYST FALDVARQEW
     LDCNDNIITK VSEAEVMDNS SSSGYIFIYN RLEDPYSRL
//