ID A0A0D9QL54_PLAFR Unreviewed; 1216 AA.
AC A0A0D9QL54;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Tr-type G domain-containing protein {ECO:0000259|PROSITE:PS51722};
GN ORFNames=AK88_02541 {ECO:0000313|EMBL:KJP87785.1};
OS Plasmodium fragile.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5857 {ECO:0000313|EMBL:KJP87785.1, ECO:0000313|Proteomes:UP000054561};
RN [1] {ECO:0000313|EMBL:KJP87785.1, ECO:0000313|Proteomes:UP000054561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=nilgiri {ECO:0000313|Proteomes:UP000054561};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Duraisingh M., Young S.K., Zeng Q., Gargeya S., Abouelleil A.,
RA Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium fragile nilgiri.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ001669; KJP87785.1; -; Genomic_DNA.
DR RefSeq; XP_012335589.1; XM_012480166.1.
DR AlphaFoldDB; A0A0D9QL54; -.
DR EnsemblProtists; KJP87785; KJP87785; AK88_02541.
DR GeneID; 24267855; -.
DR VEuPathDB; PlasmoDB:AK88_02541; -.
DR OMA; YIFRPIR; -.
DR OrthoDB; 166721at2759; -.
DR Proteomes; UP000054561; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 169..453
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..39
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..78
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1216 AA; 138539 MW; 6BC8C8FA4364739F CRC64;
MESTSNLYDE FGNYIGEDID SDGDYSDGDQ DDDMSDGVDQ EADSASGGDS NADSHEGSDE
GSDEDSDEDS DGDGGSEDES EGGGEKRLGE NMDELQRAYE GVEVFVEQED TQDIEEATIN
KINTNVERIS FIKKLDVEAN RKNFDLIETS LPNNTFSFKY MSQLMSQTEF IKNICIAGHF
HHGKTTLIDR IIEFTREKKD SKTKLTYVNG IGSGGNPNSG TVSFFNVNTE MEGVLVKRSS
LRKNNASMVT PFNAKKIDHL INYTDTRLDE QARGLSIKAI PISLILQNKM YENIPNNILL
NKKKNNLKYK SYLFNIMDTP GHVNFFDEFL CAVNICECCC LVVDVTDGCM YVTENVIKTC
IYENVKMVLI LNCVDKLIMD LRLPPNDAYH KINYTIEEIN KKIESFCDML NKSVKEKKKF
LLSPLKNNVL FASSIYGVFF TLKSFSKIYC NLYNAYNIDI DEFAQHLWGD IYFNEKDFSF
ASSPLYSNQR RSFVEFILNP IYKIFGYVCS EEKEFLIPFL KNFNITLKKN DYLFNNKYLL
KKINGMIFED TTAFVDVILD NCPSPLENAK QKTRQIYSGS LKTKLCYDMM RCLKGDQTDN
LMVYIIKNYH RPECIILDLF GRVMCGTIRK GQTVRILGEG YSPSDDEDMI TRVVTHLWIY
EGRYRVEVDE VPAGNFVLIG GVDICINKTC TITNVKKRRN GNAKELRKVQ LSGTKGTGIV
PTSGSLSNLK KEERALLLED EEETEIFYPL HKKFKYINCA NSVFKVACEP INPSELPKML
EGLRKIDKTY PMCSTKVEES GEHIILGTGE LYLDCILHDL RKLYGDLEIK VSDPVVQFNE
TVIETSALNC FAETPNKKNK IHMIVEPMQK ELMDDIVQGL VHLNKGERDA NVEEYLRTVD
RLLREERSAG HEEHAVNDSD QSDRSQQSDQ SDHVGVNGAE EEDVASDKRT NTLNYNLDKN
VISLLTEKHN WDMLSIRSIW AFGPESNSPN ILVDDSLYKE TNKENLYSIK ENIIQGFCWA
TKEGPLIEEC MKNVKVKILK GEIDDDPINR GAGQIIPTTR RAIYSSFLLA TPRLMEPILF
TEIICSGDSV SSVYNVLSRR RGHVLKDFPK VGTPLYMVHA YLPAIESFGF ETDLRTHTSG
QAFCLSMFDH WHIVPGDPLD KSVVLRPLEP APIQHLAREF LLKTRRRKGL TEDVTINRFF
DDPMLLNIKD EFAEYF
//
