ID A0A0D9QXV2_CHLSB Unreviewed; 1773 AA.
AC A0A0D9QXV2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=SET binding factor 1 {ECO:0000313|Ensembl:ENSCSAP00000001191.1};
GN Name=SBF1 {ECO:0000313|Ensembl:ENSCSAP00000001191.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000001191.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000001191.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000001191.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; AQIB01154073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000001191; -.
DR Ensembl; ENSCSAT00000002898.1; ENSCSAP00000001191.1; ENSCSAG00000004869.1.
DR eggNOG; KOG1090; Eukaryota.
DR eggNOG; KOG2080; Eukaryota.
DR GeneTree; ENSGT00940000155263; -.
DR OMA; FQHWEVV; -.
DR Proteomes; UP000029965; Chromosome 19.
DR Bgee; ENSCSAG00000004869; Expressed in prefrontal cortex and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF43; MYOTUBULARIN-RELATED PROTEIN 5; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 1..345
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1026..1502
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1667..1771
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1588..1607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1629..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..994
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1773 AA; 197752 MW; 8EBE4FD673454978 CRC64;
MTREEDATER EEEEDEGGQT HLSPTAPAPS AQLFAPKTLV LVSRLDHAEV FRNSLGLIYA
IHVEGLNVCL ENVIGNLLTC TVPLAGGSQR TISLGAGDRQ VIQTPLADSL PVSRCSVALL
FRQLGITNVL SLFCAALTEH KVLFLSRSYQ RLADACRGLL ALLFPLRYSF TYVPILPAQL
LEVLSTPTPF IIGVNAAFQA ETQELLDVIV ADLDGGTVAI PECVHIPPLP EPLQSQTHSV
LSMVLDPELE LADLAFPPPT TSTSSLKMQD KELRAVFLRL FAQLLQGYRW CLHVVRIHPE
PVIRFHKAAF LGQRGLVEDD FLMKVLEGMA FAGFVSERGV PYRPTDLFDE LVAHEVARMR
ADENHPQRVL RHVQELAEQL YKNENPYPAV AMHKVQRPGE SSHLRRVPRP FPRLDEGTVQ
WIVDQAAAKM QGAPPAVKAE RRTTVPSGPP MTAILERCSG LHVNSARRLE VVRNCISYVF
EGKMLEAKKL LPAVLRALKG RAARRCLAQE LHLHVQQNRA VLDHQQFDFV VRMMNCCLQD
CTSLDEHGIA AALLPLVTAF CRKLSPGVTQ FAYSCVQEHV VWSTPQFWEA MFYGDVQTHI
RALYLEPTED LAPAQEVGEA PSQEDERSAL DVASEQRRLW PTLSREKQQE LVQKEESTVF
SQAIHYANRM SYLLLPLDSS KSRLLRERAG LGDLESASNS LVTNSMAGSV AESYDTESGF
EDAETCDVAG AVVRFINRFV DKVCTESGVT SDHLKGLHVM VPDIVQMHIE TLEAVQRESR
RLPPIQKPKL LRPRLLPGEE CVLDGLRVYL LPDGREEGAG GSAGGPALLP AEGAVFLTTY
RVIFTGMPTD PLVGEQVVVR SFPVAALTKE KRISVQTPVD QLLQDGLQLR SCTFQLLKMA
FDEEVGSDSA ELFRKQLHKL RYPPDVRATF AFTLGSAHTP GRPPRVTKDK GPSLRTLSRN
LVKNAKKTIG RQHVTRKKYN PPSWEHRGQP PPEDQEDEIS VSEELEPSTL TPSSALKPSD
RMTMSSLVER ACCRDYQRLG LGTLSSSLSR AKSEPFRISP VNRMYAICRS YPGLLIVPQS
VQDNALQRVS RCYRQNRFPV VCWRSGRSKA VLLRSGGLHG KGVVGLFKAQ NAPSPGQSQA
DSSSLEQEKY LQAVVSSMPR YADASGRNTL SGFSSAHMGS HGKWGSVRTS GRSSGLGTDV
GSRLAGRDTL APPQANGGPP DPGFLRPQRA ALYILGDKAQ LKGVRPDPLQ QWELVPIEVF
EARQVKASFK KLLKACVPGC PAAEPSPASF LRSLEDSEWL IQIHKLLQVS VLVVELLDSG
SSVLVGLEDG WDITTQVVSL VQLLSDPFYR TLEGFRLLLE KEWLSFGHRF SHRGAHTLAG
QSSGVTPVFL QFLDCVHQVH LQFPMEFEFS QFYLKFLGYH HVSRRFRTFL LDSDYERIEL
GLLYEEKGER RGQLPCRSVW EYVDRLSKRT PVFYNYMYAP EDTEVLRPYS NVSNLKVWDF
YTEETLAEGP PYDWELAQGP PEPPEEERSD GGAPQSRRRV VWPCYDSCPR TQPDAISRLL
EELQRLETEL GRPAERWKDT WDRVKAAQRL EGRPDGRGTP SSLLVSTAPH HRRSLGVYLQ
EGPVGSTLSL SLDSDQSSGS TASGSRQAAR RSTSTLYSQF QTAESENRSY EGTLYKKGAF
MKPWKARWFV LDKTKHQLRY YDHRVDTECK GVIDLAEVEA VAPGTPTMGA PKTVDEKAFF
DVKTTRRVYN FCAQDVPSAQ QWVDRIQSCL SDA
//
