ID A0A0D9R0H0_CHLSB Unreviewed; 469 AA.
AC A0A0D9R0H0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Keratin, type II cytoskeletal 7 {ECO:0000256|ARBA:ARBA00039431};
DE AltName: Full=Cytokeratin-7 {ECO:0000256|ARBA:ARBA00042963};
DE AltName: Full=Keratin-7 {ECO:0000256|ARBA:ARBA00042887};
DE AltName: Full=Type-II keratin Kb7 {ECO:0000256|ARBA:ARBA00043134};
GN Name=KRT7 {ECO:0000313|Ensembl:ENSCSAP00000002109.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000002109.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000002109.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000002109.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit
CC EIF3S10. Interacts with GPER1. {ECO:0000256|ARBA:ARBA00038822}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01022898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008001516.1; XM_008003325.1.
DR AlphaFoldDB; A0A0D9R0H0; -.
DR STRING; 60711.ENSCSAP00000002109; -.
DR Ensembl; ENSCSAT00000003836.1; ENSCSAP00000002109.1; ENSCSAG00000005799.1.
DR GeneID; 103238341; -.
DR KEGG; csab:103238341; -.
DR CTD; 3855; -.
DR eggNOG; ENOG502QURK; Eukaryota.
DR GeneTree; ENSGT00940000161303; -.
DR OMA; QRSKQEM; -.
DR OrthoDB; 4640531at2759; -.
DR BioGRID-ORCS; 103238341; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 11.
DR Bgee; ENSCSAG00000005799; Expressed in fibroblast and 2 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 91..403
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 446..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 88..115
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 166..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 301..381
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 455..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 51570 MW; 71ACCA9592AB30C1 CRC64;
MSIHFSSPVF TSRSAAFSGR GAQARLSSAR PGGLGSSSLY GLGASRPRVA VRSAYGGPVG
AGIREVTINQ SLLAPLRLEA DPSLQRVRQE EREQIKTLNN KFASFIDKVR FLEQQNKLLE
TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG QLEALQVDGG RLEAELRSMQ DVVEDFKNKY
EDEINRRAAA ENEFVVLKKD VDAAYMSKVE LEAKVDALND EINFLRTLNE MELTELQSQI
SDTSVVLSMD NSRSLDLDSI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD
LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA RAKQEELEAA
LQRAKQDMVR QLREYQELMS VKLALDIEIA TYRKLLEGEE SRLAGDGVGA VNISVVNSTG
GSSNGGGIGL TLGGTMGSNA LSFSSSAGPG PLKAYSIRTT STSRRSARN
//
