ID A0A0D9RBW9_CHLSB Unreviewed; 475 AA.
AC A0A0D9RBW9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Kremen protein {ECO:0000256|PIRNR:PIRNR036961};
DE AltName: Full=Kringle-containing protein marking the eye and the nose {ECO:0000256|PIRNR:PIRNR036961};
GN Name=KREMEN1 {ECO:0000313|Ensembl:ENSCSAP00000006108.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000006108.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000006108.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000006108.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to
CC inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt
CC receptors LRP5 and LRP6. {ECO:0000256|PIRNR:PIRNR036961}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|PIRNR:PIRNR036961};
CC Single-pass type I membrane protein {ECO:0000256|PIRNR:PIRNR036961}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; AQIB01136861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007973487.1; XM_007975296.1.
DR AlphaFoldDB; A0A0D9RBW9; -.
DR STRING; 60711.ENSCSAP00000006108; -.
DR Ensembl; ENSCSAT00000007949.1; ENSCSAP00000006108.1; ENSCSAG00000009891.1.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000158390; -.
DR OMA; SQHAGKP; -.
DR OrthoDB; 211181at2759; -.
DR BioGRID-ORCS; 103223130; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 19.
DR Bgee; ENSCSAG00000009891; Expressed in pituitary gland and 6 other cell types or tissues.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0048681; P:negative regulation of axon regeneration; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00108; KR; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR017076; Kremen.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR24269; KREMEN PROTEIN; 1.
DR PANTHER; PTHR24269:SF13; KREMEN PROTEIN 1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF01822; WSC; 1.
DR PIRSF; PIRSF036961; Kremen; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00130; KR; 1.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS51212; WSC; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|PIRNR:PIRNR036961};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR036961-50};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Membrane {ECO:0000256|PIRNR:PIRNR036961};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR036961};
KW Transmembrane helix {ECO:0000256|PIRNR:PIRNR036961};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|PIRNR:PIRNR036961}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..475
FT /note="Kremen protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002344756"
FT TRANSMEM 393..415
FT /note="Helical"
FT /evidence="ECO:0000256|PIRNR:PIRNR036961"
FT DOMAIN 33..116
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 118..212
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 216..323
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 34..116
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 57..97
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 86..111
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 124..188
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 149..169
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 153..171
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 192..200
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
FT DISULFID 216..242
FT /evidence="ECO:0000256|PIRSR:PIRSR036961-50"
SQ SEQUENCE 475 AA; 51945 MW; C3FF137237F71116 CRC64;
MAPPAARLAL LSAAALTLAA RPAPSPGLGP GPECFTANGA DYRGTQNWTA LQGGKPCLFW
NETFQHPYNT LKYPNGEGGL GEHNYCRNPD GDVSPWCYVA EHEDGVYWKY CEIPACQMPG
NLGCYKDHGN PPPLTGTSKT SNKLTIQTCI SFCRSQRFKF AGMESGYACF CGNNPDYWKY
GEAASTECNS VCFGDHTQPC GGDGRIILFD TLVGACGGNY SAMSSVVYSP DFPDTYATGR
VCYWTIRVPG ASRIHFSFPL FDIRDSADMV ELLDGYTHRV LARFHGRNRP PLSFNVSLDF
VILYFFSDRI NQAQGFAVLY QAVKEELPQE RPAVNQTVAE VITEQANLSV SAARSSKVLY
VITTSPSHPP QTVPGSNSWA PPMGAGSHRV EGWTVYGLAT LLILTVTAIV AKILLHVTFK
SHRVPASGDL RDCHQPGTSG EIWSIFYKPS TSISIFKKKL KGQSQQDDRN PLVSD
//