ID A0A0D9RU88_CHLSB Unreviewed; 307 AA.
AC A0A0D9RU88;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=N-myc and STAT interactor {ECO:0000313|Ensembl:ENSCSAP00000012177.1};
GN Name=NMI {ECO:0000313|Ensembl:ENSCSAP00000012177.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012177.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000012177.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000012177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NMI family. {ECO:0000256|ARBA:ARBA00010081}.
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DR EMBL; AQIB01014862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01014863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01014864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01014865; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01014866; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007963147.1; XM_007964956.1.
DR AlphaFoldDB; A0A0D9RU88; -.
DR STRING; 60711.ENSCSAP00000012177; -.
DR Ensembl; ENSCSAT00000014198.1; ENSCSAP00000012177.1; ENSCSAG00000016102.1.
DR KEGG; csab:103217081; -.
DR eggNOG; ENOG502QVH1; Eukaryota.
DR GeneTree; ENSGT00530000063686; -.
DR OMA; IYAQIPE; -.
DR OrthoDB; 5308373at2759; -.
DR BioGRID-ORCS; 103217081; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 10.
DR Bgee; ENSCSAG00000016102; Expressed in blood and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002281; P:macrophage activation involved in immune response; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045824; P:negative regulation of innate immune response; IEA:Ensembl.
DR GO; GO:0032687; P:negative regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032688; P:negative regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:1901223; P:negative regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:1902524; P:positive regulation of protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR CDD; cd12544; RRM_NMI; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR009909; Nmi/IFP35_dom.
DR InterPro; IPR009938; Nmi/IFP35_N.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR PANTHER; PTHR15225; INTERFERON-INDUCED PROTEIN 35/NMI N-MYC/STAT INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15225:SF4; N-MYC-INTERACTOR; 1.
DR Pfam; PF07334; IFP_35_N; 1.
DR Pfam; PF07292; NID; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 29..104
FT /note="Nmi/IFP 35"
FT /evidence="ECO:0000259|Pfam:PF07334"
FT DOMAIN 105..192
FT /note="NID"
FT /evidence="ECO:0000259|Pfam:PF07292"
FT DOMAIN 203..291
FT /note="NID"
FT /evidence="ECO:0000259|Pfam:PF07292"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..64
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 307 AA; 35140 MW; 12FE10C469189FEA CRC64;
MEADKDNTQQ VLKEHGPHEF IKDEQNKELI DEMTKENIQL KKEIQKLETE LQEATREFQI
KEDIPETKMK FLAVETPEND SQLSNISCSF QVSSKVPYEL QKGQALITFE KEEVAQNVVS
MSKHQVRIKD INLEVTAKPV PLNSGVRFQV YVEVSKMKIN VTEIPDTLPE DQMRDKLELS
FCKSRNGGGE VDHADYDRQS GSAVITFVET GVADKILKKK DYPLYINQTC HRVTVSPYTE
IHLRKYQIFS GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLDQP
HIAYFEE
//
