ID A0A0D9RX98_CHLSB Unreviewed; 1248 AA.
AC A0A0D9RX98;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA repair protein REV1 {ECO:0000256|ARBA:ARBA00020399, ECO:0000256|PIRNR:PIRNR036573};
DE EC=2.7.7.- {ECO:0000256|PIRNR:PIRNR036573};
GN Name=REV1 {ECO:0000313|Ensembl:ENSCSAP00000013237.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013237.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013237.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013237.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Deoxycytidyl transferase involved in DNA repair. Transfers a
CC dCMP residue from dCTP to the 3'-end of a DNA primer in a template-
CC dependent reaction. May assist in the first step in the bypass of
CC abasic lesions by the insertion of a nucleotide opposite the lesion.
CC Required for normal induction of mutations by physical and chemical
CC agents. {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036573}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945, ECO:0000256|PIRNR:PIRNR036573}.
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DR EMBL; AQIB01138544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008006365.1; XM_008008174.1.
DR AlphaFoldDB; A0A0D9RX98; -.
DR STRING; 60711.ENSCSAP00000013237; -.
DR Ensembl; ENSCSAT00000015293.1; ENSCSAP00000013237.1; ENSCSAG00000017200.1.
DR GeneID; 103241114; -.
DR CTD; 51455; -.
DR eggNOG; KOG2093; Eukaryota.
DR GeneTree; ENSGT00940000156374; -.
DR OMA; IKNGMWM; -.
DR OrthoDB; 169741at2759; -.
DR BioGRID-ORCS; 103241114; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000017200; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0017125; F:deoxycytidyl transferase activity; IEA:Ensembl.
DR GO; GO:0042276; P:error-prone translesion synthesis; IEA:Ensembl.
DR GO; GO:0009411; P:response to UV; IEA:Ensembl.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR CDD; cd12145; Rev1_C; 1.
DR CDD; cd19318; Rev1_UBM2; 2.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1490; -; 1.
DR Gene3D; 6.10.250.1630; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.20.58.1280; DNA repair protein Rev1, C-terminal domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR012112; REV1.
DR InterPro; IPR031991; Rev1_C.
DR InterPro; IPR038401; Rev1_C_sf.
DR InterPro; IPR047346; Rev1_UBM1/2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00817; IMS; 2.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF21704; POLH-Rev1_HhH; 1.
DR Pfam; PF16727; REV1_C; 1.
DR Pfam; PF14377; UBM; 2.
DR PIRSF; PIRSF036573; REV1; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|PIRNR:PIRNR036573};
KW DNA repair {ECO:0000256|PIRNR:PIRNR036573};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|PIRNR:PIRNR036573};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR036573};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036573};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR036573}.
FT DOMAIN 44..131
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 419..652
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 204..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1248 AA; 137757 MW; A63A09ED7047A23B CRC64;
MRRGGWRKRA ENDGWEKWGG YMAAKVQKLE EQFRSDAALQ KDGTSSTIFS GVAIYVNGYT
DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI KELKGEKVIR PEWIVESIKA
GRLLSYIPYQ LYTKQSSVQK GLSFNPVCRP EDPVPGPSNI AKQFNNRVNH IVKKIETENE
VKVNGMNSWN EEDENNDFSF VDLEQTSPGR KQNGIPHPRG STAIFNGHTS SSNGALKTQD
CLVPMVNSVA SRLSPASSQE EDKAEKSSTD FRDCTLQQLQ QSTRNTDALR NPHRTNSVSL
SPLHSNTKIN GAHHSTVQGP SSTKSTSSVS TLSKTAPSVP SKPSDCNFIS NFYSHSRLHH
ISMWKCELTE FVNTLQRQSN GIFPGREKLK KMKTGRSALV VTDTGDVSVL SSPRHQSCIM
HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR GTGRAPLRPG ANPQLEWQYY QNKILKGKAD
IPDSSLWENP DSAQANGIDS VLSKAEIASC SYEARQLGIK NGMFFGHAKQ LCPNLQAVPY
DFHAYKEVAR TLYETLASYT HNIEAVSCDE ALVDITEILA ETKLTPDEFA NAVRMEIKDQ
TKCAASVGIG SNILLARMAT RKAKPDGQYH LKPEEVDDFI RGQLVTNLPG VGCSMESKLA
SLGIKTCGDL QYMTMAKLQK EFGPKTGQML YRFCRGLDDR PVRTEKERKS VSAEINYGIR
FTQPKEAEAF LLSLSEEIQR RLEATGMKGK RLTLKIMVRK AGAPVETAKF GGHGICDNVA
RTVTLDQATD NAKIIGKAML NMFHTMKLNI SDMRGVGIHV NQLVPTNMNP STCPSRPSVQ
SSHFPGGSYS VRDIFQVQKA KKSTEEEHKE VFRTAVDLEI PSASRTCTLP PFPTHLPTSP
DTNKAESSGK WNGLHSPVSV QSRLNLSIEV PSPSQLDQSV LEALPPDLRE QVEQVCAIQQ
AEAHGDKRKE PVNGCNTGIL PQPVGTVLLQ IPEPQESNSD TGINVIALPA FSQVDPEVFA
ALPAELQREL KAAYDQRQRQ GENSSHQQSA GASVPKNPLL HLKAAVKEKK RNKKKPIGSP
KRIQSPLRNK LPNSPAKTLP GACGSPQKLI DGFLKHEGTP AEKPLEELSA STSGVPGLSS
LQSDPAGCVR PPAPNLAGAV EFNDVKTLLR EWITTISDPM EEDILQVVKY CTDLIEEKDL
EKLDLVIKYM KRLMQQSVES VWNMAFDFIL DNVQVVLQQT YGSTLKVT
//
