ID A0A0D9S0R9_CHLSB Unreviewed; 715 AA.
AC A0A0D9S0R9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Folate hydrolase 1 {ECO:0000313|Ensembl:ENSCSAP00000014458.1};
GN Name=FOLH1 {ECO:0000313|Ensembl:ENSCSAP00000014458.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000014458.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000014458.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000014458.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AQIB01098464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01098473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9S0R9; -.
DR STRING; 60711.ENSCSAP00000014458; -.
DR Ensembl; ENSCSAT00000001621.1; ENSCSAP00000014458.1; ENSCSAG00000003592.1.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR OMA; LWNVIGT; -.
DR Proteomes; UP000029965; Chromosome 1.
DR Bgee; ENSCSAG00000003592; Expressed in Ammon's horn and 3 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1904492; F:Ac-Asp-Glu binding; IEA:Ensembl.
DR GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:Ensembl.
DR GO; GO:1904493; F:tetrahydrofolyl-poly(glutamate) polymer binding; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF36; GLUTAMATE CARBOXYPEPTIDASE 2; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Dipeptidase {ECO:0000256|ARBA:ARBA00022997};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 136..224
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 322..441
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 592..711
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 715 AA; 80534 MW; 3F43E514F747DDE8 CRC64;
MYFSGWFIKS SSEATNITPK HNMKAFLDEL KAENIKKFLH NFTQIPHLAG TEQNFQLAKQ
IQSQWKEFGL DSVELTHYDV LLSYPNKTHP NYISIINEDG NEIFNTSLFE PPPAGYENVS
DIVPPFSAFS PQGMPEGDLV YVNYARTEDF FTLERDMKIN CSGKIVIARY GKVFRGNKVK
NAQLAGAKGV ILYSDPADYF APGVKSYPDG WNLPGGGVQR GNILNLNGAG DPLTPGYPAN
EYAYRRGIAE AVGLPSIPVH PIGYYDAQKL LEKMGGSSPP DSSWRGSLKV PYNVGPGFTG
NFSTQKVKMH IHSTSEVTRI YNVIGTLRGA VEPDRYVILG GHRDSWVFGG IDPQSGAAVV
HEIVRSFGML KKEGWRPRRT ILFASWDAEE FGLLGSTEWA EENSRLLQER GVAYINADSS
IEGNYTLRVD CTPLMYSLVY NLTKELESPD EGFEGKSLYE SWTKKSPSPE FSGMPRISKL
GSGNDFEVFF QRLGIASGRA RYTKNWETNK FSSYPLYHSV YETYELVEKF YDPMFKYHLT
VAQVRGGMVF ELANSVVLPF DCRDYAVVLR KYADKIYNIS MKHPQEMKTY SVSFDSLFSA
VKNFTEIASK FSERLQDFDK SNPILLRMMN DQLMFLERAF IDPLGLPDRP FYRHIIYAPS
SHNKYAGESF PGIYDALFDI ESKVDPSQAW GEVKRQISIA AFTVQAAAET LSEVA
//
