ID A0A0D9S4M4_CHLSB Unreviewed; 1037 AA.
AC A0A0D9S4M4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Platelet endothelial aggregation receptor 1 {ECO:0000313|Ensembl:ENSCSAP00000015813.1};
GN Name=PEAR1 {ECO:0000313|Ensembl:ENSCSAP00000015813.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015813.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000015813.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000015813.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AQIB01138784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01138785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007974878.1; XM_007976687.1.
DR RefSeq; XP_007974880.1; XM_007976689.1.
DR RefSeq; XP_007974881.1; XM_007976690.1.
DR RefSeq; XP_007974882.1; XM_007976691.1.
DR RefSeq; XP_007974883.1; XM_007976692.1.
DR RefSeq; XP_007974885.1; XM_007976694.1.
DR AlphaFoldDB; A0A0D9S4M4; -.
DR STRING; 60711.ENSCSAP00000015813; -.
DR Ensembl; ENSCSAT00000000240.1; ENSCSAP00000015813.1; ENSCSAG00000002231.1.
DR GeneID; 103223820; -.
DR KEGG; csab:103223820; -.
DR CTD; 375033; -.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00940000154225; -.
DR OMA; NESCPRD; -.
DR OrthoDB; 2540323at2759; -.
DR BioGRID-ORCS; 103223820; 1 hit in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 20.
DR Bgee; ENSCSAG00000002231; Expressed in adrenal cortex and 2 other cell types or tissues.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0070527; P:platelet aggregation; IEA:Ensembl.
DR GO; GO:0010572; P:positive regulation of platelet activation; IEA:Ensembl.
DR GO; GO:0043654; P:recognition of apoptotic cell; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR24052; DELTA-RELATED; 1.
DR PANTHER; PTHR24052:SF12; PLATELET ENDOTHELIAL AGGREGATION RECEPTOR 1; 1.
DR Pfam; PF00053; Laminin_EGF; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00180; EGF_Lam; 12.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1037
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346261"
FT TRANSMEM 755..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..103
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 225..260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 268..303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 400..435
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 577..607
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 657..692
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 824..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..980
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 250..259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 293..302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 425..434
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 597..606
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 682..691
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1037 AA; 110706 MW; 4A3800CAB2E85EE1 CRC64;
MSPPLCPLLL LAVGLRLAGT LNPSDPNTCS FWESFTTTTK ESHSRPFSLL PSEPCERPWE
GPHTCPQPTV VYRTVYRQVV KTDHRQRLQC CHGFYESRGF CVPLCAQECV HGRCVAPNQC
QCVPGWRGDD CSSECAPGMW GPQCDKPCSC GNNSSCDPKS GECSCPSGLQ PPNCLQPCTP
GYYGPACQFR CQCHGARCDP QTGACFCPAE RTGPSCDLSC SQGTSGFFCP STHPCQNGGV
FQALQGSCSC PPGWMGTICS LPCPEGFHGP SCSQECRCHN GGLCDRFTGQ CRCAPGYTGD
RCREECPVGR FGQDCAETCD CAPDARCFPA NGACLCEHGF TGDRCTERLC PDGFYGLSCQ
APCTCDPEHS LSCHPMNGEC SCLPGWAGLH CNESCPQDTH GPGCQEHCLC LHGGVCQATS
GLCQCAPGYT GPHCASLCPP DTYGVNCSAR CSCENAIACS PIDGECICKE GWQRGNCSVP
CPPGTWGFGC NASCQCAHEA VCSPQTGACT CTPGWHGARC QLPCPKGKFG EGCASRCDCD
HSDGCDPVHG RCQCQAGWMG TRCHLSCPEG LWGVNCSNTC TCKNGGTCLP ENGNCVCAPG
FRGPSCQRSC QPGRYGKRCV PCKCTNHSFC HPSNGTCYCL AGWTGPDCSQ PCPPGHWGEN
CAQTCQCHHG GTCHPQDGSC ICPLGWTGHR CLLGCPLGTF GANCSQPCQC GPGEKCHPET
GACVCPPGHS GAPCRIGIQE PFTVMPTTPV AYNSVGAVIG IAVLGSLVVA LVALFIGYRH
WQKGKEHHHL AVAYSSGRLD GSEYVMPDVP PSYSHYYSNP SYHTLSQCSP NPPPPNKVPG
PLFASLQAPE RSGGAHGHDN HTTLPADWKH RREPPPGPLN RGSSRLDRSY SYSYNNGPGP
FYNKGLISEE ELGASVASLS SENPYATIRD LPSLPGGPRE SSYMEMKGPP SGSPPRQPPQ
FWDSQRRRQP PPQRDSGTYE QPSPLIHDRD PVGSQPPLPP GLPPGHYDSP KNSHIPGHYD
LPPVRHPPSP PLRRQDR
//
