UniProt: A0A0D9S5M2

Database: UniProt
Entry: A0A0D9S5M2_CHLSB

LinkDB:  A0A0D9S5M2_CHLSB 
Original site:  A0A0D9S5M2_CHLSB

All links

Ontology (11)   
   GO (11)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (17)   
   InterPro (9)   
   Pfam (3)   
   PROSITE (4)   
   SMART (1)   
All databases (36)   

Download RDF

ID   A0A0D9S5M2_CHLSB        Unreviewed;      1270 AA.
AC   A0A0D9S5M2;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN   Name=NPR1 {ECO:0000313|Ensembl:ENSCSAP00000016161.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000016161.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000016161.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000016161.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AQIB01138996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_007975240.1; XM_007977049.1.
DR   AlphaFoldDB; A0A0D9S5M2; -.
DR   STRING; 60711.ENSCSAP00000016161; -.
DR   Ensembl; ENSCSAT00000016659.1; ENSCSAP00000016161.1; ENSCSAG00000001869.1.
DR   GeneID; 103223952; -.
DR   KEGG; csab:103223952; -.
DR   CTD; 4881; -.
DR   eggNOG; KOG1023; Eukaryota.
DR   GeneTree; ENSGT00940000156223; -.
DR   OMA; KCAYEKS; -.
DR   OrthoDB; 3683909at2759; -.
DR   BioGRID-ORCS; 103223952; 1 hit in 9 CRISPR screens.
DR   Proteomes; UP000029965; Chromosome 20.
DR   Bgee; ENSCSAG00000001869; Expressed in adrenal cortex and 3 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016941; F:natriuretic peptide receptor activity; IEA:Ensembl.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IEA:Ensembl.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:Ensembl.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06385; PBP1_NPR_A; 1.
DR   CDD; cd14042; PK_GC-A_B; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR001170; ANPR/GUC.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920:SF300; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1; 1.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00255; NATPEPTIDER.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00458; ANF_RECEPTORS; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          737..1014
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          1085..1215
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          161..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1015..1053
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1270 AA;  141322 MW;  7F5B3ABDCFE13E30 CRC64;
     MVHREARGLG GGEEGVKDPG LALQSRSLGG EAAGREGSEL GSGPPRFPPD SWRLGPAGRP
     FWHTPWGRRT RTLQTHTPLS SLARPLPSFF TKRSLAPFLS LSLSLSLTVL PLTRTHTPSC
     SHSGPLRSDV LLAPTCSAVP CAPPSVAPLA LSAQTVAATG GLKPRGERPL PAPAPSHRDA
     PDAWDRPLSR WGPRRPWWER SPAPVPAETM PEPRRPAGSR LRLLLLLLLP PLLLLLRGSH
     AGNLTVAVVL PLANTSYPWS WARVGPAVEL ALARVKARPD LLPGWTVRTV LGSSENALGV
     CSDTAAPLAA VDLKWEHNPA AFLGPGCVYA AAPVGRFTAH WRVPLLTAGA PALGFGVKDE
     YALTTRAGPS YAKLGDFVAA LHRRLGWERQ ALMLYAYRPG DEEHCFFLVE GLFMRVRERL
     NITVDHLEFA EDDLSHYTRL LRTMPRKGRV IYICSSPDAF RTLMLLALEA GLCGEDYVFF
     HLDIFGQSLQ GGQGPAPRRP WERGDGHDVS ARQAFQAAKI ITYKEPDNPE YLEFLKQLKH
     LAREQFNFTM EDGLVNTIPA SFHDGLLLYI QAVTETLAHG GTVTDGENIT QRMWNRSFQG
     VTGYLKIDSS GDRETDFSLW DMDPETGAFR VVLNYNGTSQ ELVAVSGRKL NWPLGYPPPD
     IPKCGFDNED PACNQDHLST LEVLALVGSL SLLSILIVSF FIYRKMQLEK ELASELWRVR
     WEDVEPSSLE RHLRSAGSRL TLSGRGSNYG SLLTTEGQFQ VFAKTAYYKG NLVAVKRVNR
     KRIELTRKVL FELKHMRDVQ NEHLTRFVGA CTDPPNICIL TEYCPRGSLQ DILENESITL
     DWMFRYSLTN DIVKGMLFLH NGAICSHGNL KSSNCVVDGR FVLKITDYGL ESFRDLDPEQ
     GHTLYAKKLW TAPELLRMAS PPVRGSQAGD IYSFGIILQE IALRSGVFHV EGLDLSPKEI
     IERVTRGEQP PFRPSLALQS HLEELGLLMQ RCWAEDPQER PPFQQIRLTL RKFNRENSSN
     ILDNLLSRME QYANNLEELV EERTQAYLEE KRKAEALLYQ ILPHSVAEQL KRGETVQAEA
     FDSVTIYFSD IVGFTALSAE STPMQVVTLL NDLYTCFDAV IDNFDVYKVE TIGDAYMVVS
     GLPVRNGRLH ACEVARMALA LLDAVRSFRI RHRPQEQLRL RIGIHTGPVC AGVVGLKMPR
     YCLFGDTVNT ASRMESNGEA LKIHLSSETK AVLEEFGGFE LELRGDVEMK GKGKVRTYWL
     LGERGSSTRG
//

DBGET integrated database retrieval system