ID A0A0D9SBM5_CHLSB Unreviewed; 92 AA.
AC A0A0D9SBM5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Small nuclear ribonucleoprotein E {ECO:0000256|ARBA:ARBA00022037, ECO:0000256|RuleBase:RU365053};
DE Short=snRNP-E {ECO:0000256|RuleBase:RU365053};
DE AltName: Full=Sm protein E {ECO:0000256|ARBA:ARBA00030143, ECO:0000256|RuleBase:RU365053};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000018264.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000018264.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000018264.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in pre-mRNA splicing as a core component of the
CC spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins
CC (snRNPs), the building blocks of the spliceosome. Component of both the
CC pre-catalytic spliceosome B complex and activated spliceosome C
CC complexes. As a component of the minor spliceosome, involved in the
CC splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it
CC is involved in histone 3'-end processing.
CC {ECO:0000256|RuleBase:RU365053}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU365053}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU365053}.
CC Note=SMN-mediated assembly into core snRNPs occurs in the cytosol
CC before SMN-mediated transport to the nucleus to be included in
CC spliceosomes. {ECO:0000256|RuleBase:RU365053}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC {ECO:0000256|ARBA:ARBA00006850, ECO:0000256|RuleBase:RU365053}.
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DR EMBL; AQIB01134995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007987042.1; XM_007988851.1.
DR RefSeq; XP_008011945.1; XM_008013754.1.
DR AlphaFoldDB; A0A0D9SBM5; -.
DR SMR; A0A0D9SBM5; -.
DR STRING; 60711.ENSCSAP00000018264; -.
DR Ensembl; ENSCSAT00000018832.1; ENSCSAP00000018264.1; ENSCSAG00000018742.1.
DR GeneID; 103230267; -.
DR GeneID; 103244060; -.
DR KEGG; csab:103230267; -.
DR KEGG; csab:103244060; -.
DR CTD; 6635; -.
DR eggNOG; KOG1774; Eukaryota.
DR GeneTree; ENSGT00390000012818; -.
DR OMA; VPPINCI; -.
DR OrthoDB; 5113494at2759; -.
DR BioGRID-ORCS; 103230267; 5 hits in 14 CRISPR screens.
DR BioGRID-ORCS; 103244060; 0 hits in 5 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 2.
DR Bgee; ENSCSAG00000018742; Expressed in fibroblast and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005685; C:U1 snRNP; IEA:UniProtKB-UniRule.
DR GO; GO:0005686; C:U2 snRNP; IEA:UniProtKB-UniRule.
DR GO; GO:0005687; C:U4 snRNP; IEA:UniProtKB-UniRule.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005682; C:U5 snRNP; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR CDD; cd01718; Sm_E; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR001163; Sm_dom_euk/arc.
DR InterPro; IPR027078; snRNP-E.
DR PANTHER; PTHR11193; SMALL NUCLEAR RIBONUCLEOPROTEIN E; 1.
DR PANTHER; PTHR11193:SF9; SMALL NUCLEAR RIBONUCLEOPROTEIN E; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS52002; SM; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW mRNA processing {ECO:0000256|RuleBase:RU365053};
KW mRNA splicing {ECO:0000256|RuleBase:RU365053};
KW Nucleus {ECO:0000256|RuleBase:RU365053};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|RuleBase:RU365053};
KW RNA-binding {ECO:0000256|RuleBase:RU365053};
KW Spliceosome {ECO:0000256|RuleBase:RU365053}.
FT DOMAIN 18..92
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
SQ SEQUENCE 92 AA; 10804 MW; 7D8881CE1F4FA2FD CRC64;
MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD
AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN
//
