ID A0A0D9ZWV5_9ORYZ Unreviewed; 2436 AA.
AC A0A0D9ZWV5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
OS Oryza glumipatula.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=40148 {ECO:0000313|EnsemblPlants:OGLUM05G10750.2};
RN [1] {ECO:0000313|EnsemblPlants:OGLUM05G10750.2}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.A., Panaud O., Oliveira A.C.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:OGLUM05G10750.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR STRING; 40148.A0A0D9ZWV5; -.
DR EnsemblPlants; OGLUM05G10750.2; OGLUM05G10750.2; OGLUM05G10750.
DR Gramene; OGLUM05G10750.2; OGLUM05G10750.2; OGLUM05G10750.
DR eggNOG; KOG0368; Eukaryota.
DR UniPathway; UPA00655; UER00711.
DR Proteomes; UP000026961; Unassembled WGS sequence.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF4; ACETYL-COA CARBOXYLASE 2; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000026961}.
FT DOMAIN 264..771
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 417..611
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 879..953
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1679..2020
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 2024..2338
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT REGION 144..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2436 AA; 269991 MW; 58616D0DFBDE391F CRC64;
MPMRPWEFII LGRTAPISPP PLGISAFSRA LRLRLAAVVD AARIQTPPRV AFSAFFFFFF
FFSEGLSREG TAARLPALIY RVPFIPCLLQ LQIRAPHADP RPAGESAADF THLGIYLLFV
WHYTFEKPTT MTSTHVATLG VGAQAPPRHQ KKSAGTAFVS SGSSRPSYRK NGQRTRSLRE
ESNGGVSDSK KLNHSIRQGL AGIIDLPNDA ASEVDISHGS EDPRGPTVPG SYQMNGIINE
THNGRHASVS KVVEFCTALG GKTPIHSVLV ANNGMAAAKF MRSVRTWAND TFGSEKAIQL
IAMATPEDLR INAEHIRIAD QFVEVPGGTN NNNYANVQLI VEIAERTGVS AVWPGWGHAS
ENPELPDALT AKGIVFLGPP ASSMHALGDK VGSALIAQAA GVPTLAWSGS HVEVPLECCL
DSIPDEMYRK ACVTTTEEAV ASCQVVGYPA MIKASWGGGG KGIRKVHNDD EVRTLFKQVQ
GEVPGSPIFI MRLAAQSRHL EVQLLCDQYG NVAALHSRDC SVQRRHQKII EEGPVTVAPR
ETVKELEQAA RRLAKAVGYV GAATVEYLYS METGEYYFLE LNPRLQVEHP VTEWIAEVNL
PAAQVAVGMG IPLWQIPEIR RFYGMNHGGG YDLWRKTAAL ATPFNFDEVD SKWPKGHCVA
VRITSEDPDD GFKPTGGKVK EISFKSKPNV WAYFSVKSGG GIHEFADSQF GHVFAYGTTR
SAAITTMALA LKEVQIRGEI HSNVDYTVDL LNASDFRENK IHTGWLDTRI AMRVQAERPP
WYISVVGGAL YKTVTANTAT VSDYVGYLTK GQIPPKIDTV RSGHGSYRLR MNGSTVDANV
QTLCDGGLLM QLDGNSHVIY AEEEASGTRL LIDGKTCMLQ NDHDPSKLLA ETPCKLLRFL
VADGAHVDAD VPYAEVEVMK MCMPLLSPAS GVIHVVMSEG QAMQAGDLIA RLDLDDPSAV
KRAEPFEDTF PQMGLPIAAS GQVHKLCAAS LNACRMILAG YEHDIDKVVP ELVYCLDTPE
LPFLQWEELM SVLATRLPRN LKSELEGKYE EYKVKFDSGI INDFPANMLR VIIEENLACG
SEKEKATNER LVEPLMSLLK SYEGGRESHA HFVVKSLFEE YLYVEELFSD GIQSDVIERL
RLQHSKDLQK VVDIVLSHQS VRNKTKLILK LMESLVYPNP AAYRDQLIRF SSLNHKAYYK
LALKASELLE QTKLSDLCAR IARSLSELEM FTEESKVLSM HKREIAIKES MEDLVTAPLP
VEDALISLFD CSDTTVQQRV IETYIARLYQ PHLVKDSIKM KWIESGVIAL WEFPEGYFDA
RNGGAVLGDK RWGAMVIVKS LESLSMAIRF ALKETSHYTS SEGNMMHIAL LGADNKMNII
QESGDDADRI AKLPLILKDN VTDLHASGVK TISFIVQRDE ARMTMRRTFL WSDEKLSYEE
EPILRHVEPP LSALLELDKL KVKGYNEMKY TPSRDRQWHI YTLRNTENPK MLHRVFFRTL
VRQPSVSNKF SSGQIGDMEV GSAEEPLSFT STSILRSLMT AIEELELHAI RTGHSHMYLH
VLKEQKLLDL VPVSGNTVLD VGQDEATAYS LLKEMAMKIH ELVGARMHHL SVCQWEVKLK
LDCDGPASGT WRIVTTNVTS HTCTVDIYRE MEDKESRKLV YHPATPAAGP LHGVALNNPY
QPLSVIDLKR CSARNNRTTY CYDFPLAFET AVRKSWSSST SGASKGVENA QCYVKATELV
FADKHGSWGT PLVQMDRPAG LNDIGMVAWT LKMSTPEFPS GREIIVVAND ITFRAGSFGP
REDAFFEAVT NLACEKKLPL IYLAANSGAR IGIADEVKSC FRVGWSDDGN PERGFQYIYL
SEEDYARIGT SVIAHKMQLD SGEIRWVIDS VVGKEDGLGV ENIHGSAAIA SAYSRAYKET
FTLTFVTGRT VGIGAYLARL GIRCIQRLDQ PIILTGYSAL NKLLGREVYS SHMQLGGPKI
MATNGVVHLT VSDDLEGVSN ILRWLSYVPA YIGGPLPVTT PLDPPDRPVA YIPENSCDPR
AAIRGVDDSQ GKWLGGMFDK DSFVETFEGW AKTVVTGRAK LGGIPVGVIA VETQTMMQTI
PADPGQLDSR EQSVPRAGQV WFPDSATKTA QALLDFNREG LPLFILANWR GFSGGQRDLF
EGILQAGSTI VENLRTYNQP AFVYIPMAAE LRGGAWVVVD SKINPDRIEC YAERTAKGNV
LEPQGLIEIK FRSEELQDCM SRLDPTLIDL KAKLEVANKN GSADTKSLQE NIEARTKQLM
PLYTQIAIRF AELHDTSLRM AAKGVIKKVV DWEESRSFFY KRLRRRISED VLAKEIRAVA
GEQFSHQPAI ELIKKWYSAS HAAEWDDDDA FVAWMDNPEN YKDYIQDLKA QRVSQSLSSL
SDSSSDLQAL PQGLSMLLDK MDPSRRAQLV EEIRKA
//
