ID   A0A0E0MRS4_ORYRU        Unreviewed;      1555 AA.
AC   A0A0E0MRS4;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=Tower domain-containing protein {ECO:0000259|SMART:SM01341};
OS   Oryza rufipogon (Brownbeard rice) (Asian wild rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=4529 {ECO:0000313|EnsemblPlants:ORUFI01G04350.2, ECO:0000313|Proteomes:UP000008022};
RN   [1] {ECO:0000313|Proteomes:UP000008022}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=cv. W1943 {ECO:0000313|Proteomes:UP000008022};
RA   Zhao Q.;
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:ORUFI01G04350.2}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EnsemblPlants; ORUFI01G04350.2; ORUFI01G04350.2; ORUFI01G04350.
DR   Gramene; ORUFI01G04350.2; ORUFI01G04350.2; ORUFI01G04350.
DR   Proteomes; UP000008022; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   CDD; cd04493; BRCA2DBD_OB1; 1.
DR   CDD; cd04494; BRCA2DBD_OB2; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR048262; BRCA2_OB_2_dom.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR015205; Tower_dom.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   Pfam; PF00634; BRCA2; 6.
DR   SMART; SM01341; Tower; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   PROSITE; PS50138; BRCA2_REPEAT; 4.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008022};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1171..1211
FT                   /note="Tower"
FT                   /evidence="ECO:0000259|SMART:SM01341"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          741..778
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1032..1054
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1555 AA;  169754 MW;  4137F5CB901BF5C6 CRC64;
     MQRRWQVWGK PDGSLVWVPA SDGPPPPAAA ASEAPLPRPD PQPAATELGE ARSGDAIPEG
     PGAADGCSVP SMADLFNQAL DKLVAADGMA EAIEDSGKGA VFCTGLGGSV AVSERAVERA
     KALVGEVAEE ISNERRQPFG DGSNLECGLG ESNVSFKGGV HKDSLSPMFQ TGSGKMVSLS
     KGSIQKARAV LEGNAENSSV IAVQSMFHTG LVRPDPVSRS STDNAMTVLE GQTNPKQGDV
     ADVYDKENFP LFQTGSGKAV SVSVASIQKA KAVLEQNNTE NTEDFGRPDQ SLIFQTGSRR
     PVLISERSSS VVKDGGAENI VFQTGLGRPV VVSQTSIQKA RTVLDQECAK RSGHGDTNVS
     TTTFQTETPT SVLMSGGLTM NDRSVTPEGG VSMQGNFLEA DGHLPLFQTG LGRSISVSKG
     SIKRASALLE PRNITKELED EAHSDDGCAT PMFKTGSGRS ITASENSRKK AHVVLEGEEP
     VKNVNNDTGE AIAPMLHAGM QKFAPQNRNS SHKAITLMEQ GSSMKEEYID RGNEPPMFRT
     GSGKSVLISH SSVQKARAVL EEEGNMKKEN HKQLSNVDRY IPIFTSPLKT SYARTVHISS
     VGVSRAATLL GLEENTLSTQ LLGHVGDKLG TKITVERENS EHQFGVASVS GISGGCPISS
     GPAENQVLMD PHQHFAFSKT TFSDSSEQAI RFSTAGGRTM AISSDALQRA KNLLGESDLE
     VSPNNLLGHS SASACKENIQ NSTGLRKEGE PDLLKSRGNS KTEPAQFSIP AKPDRKHTDS
     LEYAVPDATL ANGNSVRLHA ARDFHPINEI PKISKPSSRC SFGTENASDT KDKARRLQMP
     SGPLIDITNY IGTHSVNTDY LAGEKRRFGG RNSISPFKRP RSSRCTIFFT LLTYNSCDQT
     EDVTDEVKLM DAKKAEKYKF KTDTGAEEFQ KMLLACGASL TYTTKEWVSN HYKWIVWKLA
     SLERCYPTRA AGKFLKVGNV LEELKYRYDR EVNNGHRSAI KKILEGNASP SLMMVLCISA
     IYSCPDLNNS KPEDDRAHTD DDNSENKSLR PAKRNMSTKI ELTDGWYSLD ASLDLALLEQ
     LEKRKLFIGQ KLRIWGASLC GWAGPVSFHE ASGTVKLMIH INGTYRARWD ETLGLCKHAG
     VPLAFKCIKA SGGRVPRTLV GVTRIYPVMY RERFSDGRFV VRSERMERKA LQLYHQRVSK
     IAEDIQSEHG EHCDNTDDND EGAKICKMLE RAAEPEILMS SMNSEQLLSF SYYQEKQKIV
     RQNEVAKKVE NALKVAGLSS RDVTPFLKVR VTGLISKHSA TKSGCREGLI TIWNPTEKQK
     SDLVEGQIYS VTGLLASSYF TEVSYLSGRG SSTAWTPLAT AQTTNFEPFF TPRKAVELSH
     FGEVPLTSEF DIAGVILYVG NVYLLNNQNR QWLFLTDGSK FISGEKYEEQ DDCLLAVSFS
     SKTTGEDSAF FNYALSGHIV GFSNLVKRDK DQMRHVWVAE ATESSTYSLS HEIPKKSHLK
     EAATSAEKWA SNSHPMIQHL KERVLQIVGD SGRDWHVEGQ ISGFGHEISC WRGNG
//