ID A0A0E1RUH5_COCIM Unreviewed; 847 AA.
AC A0A0E1RUH5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=CIMG_10241 {ECO:0000313|EMBL:EAS27636.2};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS27636.2, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704915; EAS27636.2; -; Genomic_DNA.
DR RefSeq; XP_001239219.2; XM_001239218.2.
DR AlphaFoldDB; A0A0E1RUH5; -.
DR GeneID; 4558080; -.
DR KEGG; cim:CIMG_10241; -.
DR VEuPathDB; FungiDB:CIMG_10241; -.
DR InParanoid; A0A0E1RUH5; -.
DR OMA; WTHIQDD; -.
DR OrthoDB; 24739at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 170..417
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 126..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..759
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 95168 MW; 200DC022A0B58FA2 CRC64;
MSSITEDRTL HNFILENYPD EALLETLEEY AYSPEATKAI SETPSTHSFR EWIRSIRSSK
ASLPQGPSRF VTDWPEDEGL DDSYRMLPKE RISGDDASFV TSSSFLHSVK TASMSLASLS
ILNRGRSNTQ TSSHHRSSTF SGSDPRKSID SNRLGSTPPF DEVAWRHAIQ RYQIIQELID
TEVSYISILK NLSQGLSLVL IAPSGVHQSV DKLITFHERL LASLRNRPTV STSNANLNTR
GPTRRMKYAN ENDPNPSTIG ANSIFLAPKK LRWQASPRIR SPTVLMATPK EAADVACILK
AHLPGFLVYK EYLMKYPSVQ SEIDQLRQTK QNWQAYDQGL EALFRTVQPF SSREKYANHA
RTIADLLIQP VQRLCKYQLF LTDLMKCTPA TQCLVTHETL RQAHQETVNV AQEVNSGSDD
PIAIDRYRKT MELQKRLEFP SSQDYHDILK TYGPLKVCGV LHVAYQIGET VSGSYMVCAL
FDSYILLATS SSDREKFRVM AIIHIRGSRL EEPANGIGAI PSNGWLTLCL HCSGTPYSWK
LIFTFEHSLV ELIFSACSEK EETEWLRNLI IQINPEQEAR SETVGQPVRN SFIYFALKPL
QAVILNGRLL SVARRSSIHG TLITTGSPDY LPIHIKGTTA LPTNQATRPP LGRSQSVQNS
RRDIVLAPKR QKRVKMEKRL VDIWTRDVVP YPGMPLGIGE SFMRTSTDVL MGKFTSLPQF
ARRTNSNRIS IKNNSVEQFS IPKSENHKME AEDEDSINNS PTKETGQGQG DDKTGLQKAA
TDAPSTQRRG FMSLRKKHSN LVQRAIGEAP SEVRYKGSRQ SLRKRLSVAL FKSSSPGKSR
RSNSVEA
//
