ID   A0A0E1S036_COCIM        Unreviewed;      1320 AA.
AC   A0A0E1S036;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=VPS9 domain-containing protein {ECO:0000313|EMBL:EAS27674.2};
GN   ORFNames=CIMG_10279 {ECO:0000313|EMBL:EAS27674.2};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS27674.2, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SIMILARITY: Belongs to the UPF0507 family.
CC       {ECO:0000256|ARBA:ARBA00007428}.
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DR   EMBL; GG704915; EAS27674.2; -; Genomic_DNA.
DR   RefSeq; XP_001239257.2; XM_001239256.2.
DR   GeneID; 4558180; -.
DR   KEGG; cim:CIMG_10279; -.
DR   VEuPathDB; FungiDB:CIMG_10279; -.
DR   InParanoid; A0A0E1S036; -.
DR   OMA; HFPMIAR; -.
DR   OrthoDB; 1387097at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR003123; VPS9.
DR   InterPro; IPR037191; VPS9_dom_sf.
DR   PANTHER; PTHR24170; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27; 1.
DR   PANTHER; PTHR24170:SF1; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED; 1.
DR   Pfam; PF13857; Ank_5; 1.
DR   Pfam; PF02204; VPS9; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF109993; VPS9 domain; 1.
DR   PROSITE; PS51205; VPS9; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT   DOMAIN          361..518
FT                   /note="VPS9"
FT                   /evidence="ECO:0000259|PROSITE:PS51205"
FT   REGION          247..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1320 AA;  147597 MW;  92B04499D888DDD5 CRC64;
     MPPLNPFLRA FFRSVLPSQC VPVQNHILLV PTTESLVNAR DRDSNTPYID LVHSEEFLGS
     HVLRIPASTS AKDALSGPRD ARGKARQMTT ANGRTVAIRE SMVFSNKGTA KEVTFSFGVF
     KFEAQLVWLT RLAGFKNLNQ AILLSDILYY VPGSESQPWL IYYISKPLLG IYDPGGIVQA
     AVPGFPSQYP EFLNSSPGCD SGSLGFARKD VQSFGELLAN FPMIARQMQP GLERLFREFG
     KELGKPLPPP PSRFSSMNSE NEADNVDETA SIRSTSSCTQ KTLPFNSLEY FEDDEDLMRR
     ALETAVTAAI DLFRLVDRQQ LSLLGATTNL TGPMVERLIE RYVTEQVHDS LLFPRICGCR
     KTEDTELDIR IRQMESIDVS QVGIPIEGGR KGKEELIHRL GRGVDEFRKM VDSTCPQEML
     KILLTTIKTV TLEYKPDSED GDVVEKKPSV LTINADILVS LLLVVVIRSQ VRHLQARLSY
     MQHFIYMDDV ESGESGYALS TFEAVLTYLR HDSRGLRKAS AKNRRLWCAT KSGKVPDMKA
     ILEPESQESL SEDSIGNGEQ EHSSQLDIYG VEDAQGPSTM ELATNGSISP HVTREPIDIP
     RVPETPRLAH VFPFQTWTPS SPPKTQPRIL KSVSMDVGSV SETSNFSLLS RSTTFGSATS
     HMEGDTSVLI LTKTQDPAGD SIPMMAVEAC QPESLKYLLS LEEYYPIQSI LEDVNSDGTT
     LLSAAVQLAH TEIVDVILAF IFQHAHPDDV RTYFAKADAR GRTVAHYLFG VPSLMSRIGA
     ALPWKKRDKH GQTPLFALCR SYDHPDYNIM VNEALTVARD SQGDGDPLRL DDHVDAKGNT
     LLHVVSDPQI LHRILCECDC DPNATNDKRF TPLMMASKYG RVDLVRILFA DPRVDPHLRE
     SRGLTAVELA KDDEVRNRID DLILFSNPPP SSVDSSGRIT AVVRSVFVED GSTRFIIKSG
     APNPPSPSEQ DQSRKMITFT VTTSRRGLAD FENLIKFLRI EHPASYIPDV PPFRSPLQIY
     SKPSRAVLHE VQERLDRLMK ILLAHPTFST HELLWEFFLM PEIQTEMLSE RSHRKAAVLV
     ERIADEYQPV TAEDIRDVEQ IVGHAQDAVR AVSNHTRSII RRGYKLHNAS IDFAEAISMC
     SYAISSLQPP TNALPHSHID AVNRFAACYT SSSLDSSPLT QYLTALTSLH TTTSAMLESL
     SRPGMLVSRL NSSTRSLARC HSTLASNSVP RKFNFPGLEE SRQRSVREQE QKILELNVEV
     EQVGKEIAWN KDVVVGELAG WTDWRGKMGK QAIREFVRTT LVREKERGKR MERCLRSLRR
//