ID A0A0E3WQE0_9EURY Unreviewed; 348 AA.
AC A0A0E3WQE0;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=tRNA-(G10-N2) methyltransferase {ECO:0000313|EMBL:AKB73385.1};
GN ORFNames=MSLAZ_0124 {ECO:0000313|EMBL:AKB73385.1};
OS Methanosarcina lacustris Z-7289.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434111 {ECO:0000313|EMBL:AKB73385.1, ECO:0000313|Proteomes:UP000033072};
RN [1] {ECO:0000313|EMBL:AKB73385.1, ECO:0000313|Proteomes:UP000033072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z-7289 {ECO:0000313|EMBL:AKB73385.1,
RC ECO:0000313|Proteomes:UP000033072};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP009515; AKB73385.1; -; Genomic_DNA.
DR RefSeq; WP_048124147.1; NZ_CP009515.1.
DR AlphaFoldDB; A0A0E3WQE0; -.
DR STRING; 1434111.MSLAZ_0124; -.
DR GeneID; 24804794; -.
DR KEGG; mls:MSLAZ_0124; -.
DR PATRIC; fig|1434111.4.peg.149; -.
DR HOGENOM; CLU_057819_1_0_2; -.
DR OrthoDB; 7080at2157; -.
DR Proteomes; UP000033072; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AKB73385.1};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000313|EMBL:AKB73385.1}.
FT DOMAIN 53..159
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 348 AA; 38515 MW; 864DAB46780A5B04 CRC64;
MLYAFELSGE HDELPVAEVF ACLKIEKLDF RLHARVDQCL VVDISGREKD VERALTGPVT
ERLAMTHHIL KVVGITENNP DAVLKLAEAF ESRGYIREGE SFVVRAKRIK HHVDFPCDSL
EQKIGGFIYR KGFRANLTSP DVEFRLILSE KAVLGTLLSS VDRSAYEART PQNKPFFHPG
VLMPRVARVI TNLSGIKPGE LLLDPFCGTA GILVEAGFVG ARVIGIDAQE KLVLGAHMNL
EAYELDYLLM EGDACRIPLK DSTIDTVVTD PPYGRSAAIL AGSLEELYSG ALEEIHRVLK
PGGIAVVVSD KAAFEYGEKA GLKVLEIYVQ RVHRSLTRII TIFQKDMD
//
