ID A0A0E8P1J8_MYCTX Unreviewed; 449 AA.
AC A0A0E8P1J8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Bifunctional o-acetylhomoserine/o-acetylserine sulfhydrylase {ECO:0000313|EMBL:QGK80450.1};
DE SubName: Full=Methionine gamma-lyase {ECO:0000313|EMBL:OMH61300.1};
DE EC=4.4.1.11 {ECO:0000313|EMBL:CFH98380.1, ECO:0000313|EMBL:OMH61300.1};
DE SubName: Full=O-acetylhomoserine sulfhydrylase {ECO:0000313|EMBL:CFH98380.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:CFH98380.1};
GN Name=metC {ECO:0000313|EMBL:CFH98380.1};
GN Synonyms=mdeA {ECO:0000313|EMBL:OMH61300.1};
GN ORFNames=A4S10_03490 {ECO:0000313|EMBL:OMH61300.1}, ERS007679_03077
GN {ECO:0000313|EMBL:COW08353.1}, ERS007681_00965
GN {ECO:0000313|EMBL:CFE38322.1}, ERS007703_03234
GN {ECO:0000313|EMBL:COW27016.1}, ERS007741_01341
GN {ECO:0000313|EMBL:COW05797.1}, ERS027661_00380
GN {ECO:0000313|EMBL:CKQ97534.1}, ERS053720_03936
GN {ECO:0000313|EMBL:CFH98380.1}, GJE03_17585
GN {ECO:0000313|EMBL:QGK80450.1}, SAMEA2683035_03674
GN {ECO:0000313|EMBL:SGI47691.1};
OS Mycobacterium tuberculosis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1773 {ECO:0000313|EMBL:CFH98380.1, ECO:0000313|Proteomes:UP000046674};
RN [1] {ECO:0000313|EMBL:CFH98380.1, ECO:0000313|Proteomes:UP000046674}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=0351H {ECO:0000313|EMBL:CFH98380.1,
RC ECO:0000313|Proteomes:UP000046674};
RG Pathogen Informatics;
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:COW27016.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K00500041 {ECO:0000313|EMBL:COW27016.1};
RA Murphy D.;
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:OMH61300.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61300.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M., Bigi F., Soria M.A.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SGI47691.1, ECO:0000313|Proteomes:UP000182946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2926STDY5723788 {ECO:0000313|EMBL:SGI47691.1,
RC ECO:0000313|Proteomes:UP000182946}, Bir 187
RC {ECO:0000313|EMBL:CKQ97534.1, ECO:0000313|Proteomes:UP000049023},
RC G09801536 {ECO:0000313|EMBL:COW08353.1,
RC ECO:0000313|Proteomes:UP000045842}, G09901357
RC {ECO:0000313|EMBL:CFE38322.1, ECO:0000313|Proteomes:UP000048289},
RC K00500041 {ECO:0000313|Proteomes:UP000038802}, and P00601463
RC {ECO:0000313|EMBL:COW05797.1, ECO:0000313|Proteomes:UP000048600};
RG Pathogen Informatics;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:OMH61300.1, ECO:0000313|Proteomes:UP000189452}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6548 {ECO:0000313|EMBL:OMH61300.1,
RC ECO:0000313|Proteomes:UP000189452};
RA Bigi M.M., Lopez B., Blanco F.C., Sasiain M.C., De La Barrera S.,
RA Ritacco V., Bigi F., Soria M.A.;
RT "Protein polymorphisms may explain contrasting epidemiological fitness of
RT two variants of a multidrug-resistant Mycobacterium tuberculosis strain.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QGK80450.1, ECO:0000313|Proteomes:UP000388593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AUSMDU00018547 {ECO:0000313|EMBL:QGK80450.1,
RC ECO:0000313|Proteomes:UP000388593};
RA Baines S.L., Goncalves da Silva A., Carter G.P., Jennison A.V.,
RA Rathnayake I.U., Graham R.M.A., Sintchenko V., Wang Q., Rockett R.J.,
RA Timms V.J., Martinez E., Ballard S., Tomita T., Isles N., Horan K.A.,
RA Pitchers W., Stinear T.P., Williamson D.A., Howden B.P., Seemann T.;
RT "Complete microbial genomes for public health in Australia and Southwest
RT Pacific.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CFOE01000083; CFE38322.1; -; Genomic_DNA.
DR EMBL; CFSW01000039; CFH98380.1; -; Genomic_DNA.
DR EMBL; CNFU01000042; CKQ97534.1; -; Genomic_DNA.
DR EMBL; CHKL01000114; COW05797.1; -; Genomic_DNA.
DR EMBL; CSAD01000505; COW08353.1; -; Genomic_DNA.
DR EMBL; CSAE01000421; COW27016.1; -; Genomic_DNA.
DR EMBL; LWDQ01000001; OMH61300.1; -; Genomic_DNA.
DR EMBL; CP045962; QGK80450.1; -; Genomic_DNA.
DR EMBL; FPTZ01000037; SGI47691.1; -; Genomic_DNA.
DR RefSeq; WP_003900028.1; NZ_WUCS01000037.1.
DR STRING; 115862.BBG46_17415; -.
DR GeneID; 45427341; -.
DR PATRIC; fig|1773.206.peg.458; -.
DR OMA; NAFQIIQ; -.
DR Proteomes; UP000038802; Unassembled WGS sequence.
DR Proteomes; UP000045842; Unassembled WGS sequence.
DR Proteomes; UP000046674; Unassembled WGS sequence.
DR Proteomes; UP000048289; Unassembled WGS sequence.
DR Proteomes; UP000048600; Unassembled WGS sequence.
DR Proteomes; UP000049023; Unassembled WGS sequence.
DR Proteomes; UP000182946; Unassembled WGS sequence.
DR Proteomes; UP000189452; Chromosome.
DR Proteomes; UP000388593; Chromosome.
DR GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Lyase {ECO:0000313|EMBL:CFH98380.1};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Transferase {ECO:0000313|EMBL:CFH98380.1}.
FT MOD_RES 220
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 449 AA; 47371 MW; 3240E5B4827B0C47 CRC64;
MSADSNSTDA DPTAHWSFET KQIHAGQHPD PTTNARALPI YATTSYTFDD TAHAAALFGL
EIPGNIYTRI GNPTTDVVEQ RIAALEGGVA ALFLSSGQAA ETFAILNLAG AGDHIVSSPR
LYGGTYNLFH YSLAKLGIEV SFVDDPDDLD TWQAAVRPNT KAFFAETISN PQIDLLDTPA
VSEVAHRNGV PLIVDNTIAT PYLIQPLAQG ADIVVHSATK YLGGHGAAIA GVIVDGGNFD
WTQGRFPGFT TPDPSYHGVV FAELGPPAFA LKARVQLLRD YGSAASPFNA FLVAQGLETL
SLRIERHVAN AQRVAEFLAA RDDVLSVNYA GLPSSPWHER AKRLAPKGTG AVLSFELAGG
IEAGKAFVNA LKLHSHVANI GDVRSLVIHP ASTTHAQLSP AEQLATGVSP GLVRLAVGIE
GIDDILADLE LGFAAARRFS ADPQSVAAF
//
