ID   A0A0F0HHI0_9ACTN        Unreviewed;       834 AA.
AC   A0A0F0HHI0;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Transporter {ECO:0000313|EMBL:KJK54301.1};
GN   ORFNames=UK14_02605 {ECO:0000313|EMBL:KJK54301.1};
OS   Streptomyces sp. NRRL F-4428.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609137 {ECO:0000313|EMBL:KJK54301.1, ECO:0000313|Proteomes:UP000033569};
RN   [1] {ECO:0000313|EMBL:KJK54301.1, ECO:0000313|Proteomes:UP000033569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-4428 {ECO:0000313|EMBL:KJK54301.1,
RC   ECO:0000313|Proteomes:UP000033569};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the reversible hydration of carbon dioxide to form
CC       bicarbonate. {ECO:0000256|ARBA:ARBA00024993}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the beta-class carbonic anhydrase family.
CC       {ECO:0000256|ARBA:ARBA00006217}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJK54301.1}.
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DR   EMBL; JYJI01000008; KJK54301.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F0HHI0; -.
DR   PATRIC; fig|1609137.3.peg.3103; -.
DR   Proteomes; UP000033569; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.40.1050.10; Carbonic anhydrase; 1.
DR   InterPro; IPR001765; Carbonic_anhydrase.
DR   InterPro; IPR036874; Carbonic_anhydrase_sf.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   PANTHER; PTHR11814:SF227; CARBONIC ANHYDRASE; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF00484; Pro_CA; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SMART; SM00947; Pro_CA; 1.
DR   SUPFAM; SSF53056; beta-carbonic anhydrase, cab; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033569};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        68..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        102..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        312..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        360..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..355
FT                   /note="SLC26A/SulP transporter"
FT                   /evidence="ECO:0000259|Pfam:PF00916"
FT   REGION          472..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..530
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..561
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   834 AA;  86042 MW;  265590D576CECB20 CRC64;
     MSASVAVFLI AMPLSLGIAL ATGAPLQAGL VAAAVGGIVA GRLGGAPLQV SGPAAGLTVV
     TAELIQRYGW RTTCAITVLA GACQLGLAAL RTARSALMVS PAIVHGMLAG IGVTIALAQL
     HIVLGGTPQS SAVANVAGLP AQLADLHPAA LGVSALTLVV LLGWPRLPGR AGRALRKVPA
     PLAAVATATA FAALAGLSLP RVDLPSWRSH ALPEMPEGPV LGLVAAVLTI TLVGSVESLL
     SAVATDKLIA SERGTDKRPP RADLDRELRG QGAANIVSGA LGGLPITGVA VRSVANVKAG
     AASRNSSMMH GFWVLLASFL LVPLLDLIPL AALAALVMAV GVQMVNVTHM RNVTRHREAL
     VYGTTIVGVV LGGVLEGVAV GIAVAVALAL HRLARTRITL ERLDSGVHRV RVRGQLTFLA
     VPRLSRVLNQ VPHDVHAVVE LDGSFMDHAA YETIQDWQQS HLAHGGTLEV TGRSGQAAQI
     NGADPADGTE TPDGPDAADG AGGVHGGDRG DDTRHAEAGH HADRSRRGQL RGTHQCCRPW
     TPWQNHCDHR ATSTRTAPAT AATMAASAEA ASNRAKGAGD GADGANGADG ADGANGAGDG
     GAPNSAPTRR RRGAGQLASG ISAFQRDTAP HVRDELARLA REGQRPSQLF ITCADSRLVT
     SMITASGPGD LFTVRNVGNL VPLPGTESTD DSVAAAIEYA VDVLKVDSIT VCGHSGCGAM
     QALLSSAPGV EATPLRRWLR HGVPSLERMA SRHHAWARIS GRLPADAVEQ LCLTNVVQQL
     EHLRAHESVA RRLAEGTLEL HGMYFHVGEA QAYLLSEGED FFDCRVFDTV GQRA
//