ID A0A0F0KNY8_9MICO Unreviewed; 385 AA.
AC A0A0F0KNY8;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Alpha-pyrone synthesis polyketide synthase-like Pks18 {ECO:0000313|EMBL:KJL22622.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:KJL22622.1};
GN ORFNames=RN50_01300 {ECO:0000313|EMBL:KJL22622.1};
OS Microbacterium foliorum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=104336 {ECO:0000313|EMBL:KJL22622.1, ECO:0000313|Proteomes:UP000033572};
RN [1] {ECO:0000313|EMBL:KJL22622.1, ECO:0000313|Proteomes:UP000033572}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12966 {ECO:0000313|EMBL:KJL22622.1,
RC ECO:0000313|Proteomes:UP000033572};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL22622.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYIU01000038; KJL22622.1; -; Genomic_DNA.
DR RefSeq; WP_045253706.1; NZ_JYIU01000038.1.
DR AlphaFoldDB; A0A0F0KNY8; -.
DR KEGG; mfol:DXT68_10650; -.
DR PATRIC; fig|104336.4.peg.1336; -.
DR Proteomes; UP000033572; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:KJL22622.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033572};
KW Transferase {ECO:0000313|EMBL:KJL22622.1}.
FT DOMAIN 76..220
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 239..379
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 160
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 385 AA; 40742 MW; C181F767699B0618 CRC64;
MSRSAVLRSL RTIVPDTVIE QDAVRDIFAA QPDVGRLATR IIGASFNGSG IDTRHTVIEE
LAPAAAPTDP PTFLDPDTGL LLSPGTKARN DVYVTEASRL FVEVARQALD ADPDVVAADI
THVITVSCTG FHAPGPEYEI VRGLGLADSV QRYHLGFMGC YASMPALRAA SQFCAADPDA
VVLVVSVELC TVHLRSSEDP DLIVANSLFA DGAAAGIVTA RDLATPVPAV RLDGFHTAIA
PEGERDMAWT IGDHGFEMIL STRVPQIIGE TIIGAVGPLY AHEGELAAAF AQGRVGERVE
HWAIHPGGRS ILDRVQERLG LSDVQMQPAR ETLREYGNMS SATILFVIRR ILDEGAADGS
RIAAMAFGPG LTAESALMTV TSGVA
//
