ID A0A0F0KS79_9MICO Unreviewed; 684 AA.
AC A0A0F0KS79;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN Name=f1pep1 {ECO:0000313|EMBL:KJL23324.1};
GN ORFNames=RL72_02112 {ECO:0000313|EMBL:KJL23324.1};
OS Microbacterium azadirachtae.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=582680 {ECO:0000313|EMBL:KJL23324.1, ECO:0000313|Proteomes:UP000033448};
RN [1] {ECO:0000313|EMBL:KJL23324.1, ECO:0000313|Proteomes:UP000033448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23848 {ECO:0000313|EMBL:KJL23324.1,
RC ECO:0000313|Proteomes:UP000033448};
RA Corretto E.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJL23324.1}.
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DR EMBL; JYIT01000077; KJL23324.1; -; Genomic_DNA.
DR RefSeq; WP_045250783.1; NZ_JYIT01000077.1.
DR AlphaFoldDB; A0A0F0KS79; -.
DR PATRIC; fig|582680.7.peg.2159; -.
DR OrthoDB; 9801421at2; -.
DR Proteomes; UP000033448; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:KJL23324.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033448}.
FT DOMAIN 7..363
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 469..659
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 684 AA; 73086 MW; 55A5C3DD006167A7 CRC64;
MSAAPHTRTE DVVEIVAGIA VPDPYRWLEG DASVPGEVAD WQRAQAAYAE ETLWSGHDRD
AIRALVEHSH EGAWPELPRS GGGLWFRAQG GRLLVADEPY GAGRILLDLR RFDEPGGTAV
LSWFAPSPDG AVLAVGVCTD GSEHNRVELV DVATGSLRDD APPEPLHSSW GGGISWFPDS
TGFAFLGLRS PAQDFRQVVY RRELGTRGPS AIEDVPIPDG SREYTRIQFS PDGRWAVAVH
RVGTPFPVAV RDLSHPGTGW RPFLPPRPET VVGHIVGDRY VTVTDLDAPR RRLVAIPLDA
EDPADPSGWT ELVPEGEAVL RSVLPVGDAL YLSEFHRTAA RVRILDHDGA ERGVVPLPGQ
GALAAPFFPL TGLAAESRDG SFVFAFSTLT TSWGVYRHRP GGALEVLQEP RIAIDATAEL
REATAADGTA IPYHVVRPRG AAAPAPVLIS AYGAAGIPTL PQYQPDLAAV LSAGGTVVQA
YLRGGGEFGS AWFRAADRER RGTRDGDLLA VAEDVLATGI AAPGRLALSG GSDGGLMCGN
AITARPDLWC AVLPRAPLLD LVGGFRNPYL EFVIRKAWGD PEDPVDVARM IALSPYERVR
PAEYPLLYVE AGANDPRCPP WQARKFVARM QAAQRGSAPI LLHVYENAGH GSGTGHDVIV
AQDAAWLACL LGALGLPDPV APQR
//
