ID A0A0F2C8J6_9MICO Unreviewed; 854 AA.
AC A0A0F2C8J6;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=kdpD {ECO:0000313|EMBL:KJQ54249.1};
GN ORFNames=RS85_01850 {ECO:0000313|EMBL:KJQ54249.1};
OS Microbacterium sp. SA39.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1263625 {ECO:0000313|EMBL:KJQ54249.1, ECO:0000313|Proteomes:UP000033425};
RN [1] {ECO:0000313|EMBL:KJQ54249.1, ECO:0000313|Proteomes:UP000033425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA39 {ECO:0000313|EMBL:KJQ54249.1,
RC ECO:0000313|Proteomes:UP000033425};
RA Corretto E., Antonielli L., Sessitsch A., Kidd P., Weyens N., Brader G.;
RT "Draft genome sequences of ten Microbacterium spp. with emphasis on heavy
RT metal contaminated environments.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJQ54249.1}.
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DR EMBL; JXRU01000033; KJQ54249.1; -; Genomic_DNA.
DR RefSeq; WP_046013154.1; NZ_JXRU01000033.1.
DR AlphaFoldDB; A0A0F2C8J6; -.
DR STRING; 1263625.RS85_01850; -.
DR PATRIC; fig|1263625.4.peg.1860; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000033425; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000033425};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KJQ54249.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 385..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 624..836
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 854 AA; 89707 MW; 18A50E508FA6E182 CRC64;
MSREHSRRGR LRVLLGAAPG VGKTFEMLAE GRRLRDEGHD VVIAIVETHE RAATQAQTVG
LEEVPRRIDD HRGVPLTELD LDAVLSRAPE IALVDELAHT NSPGSRHPKR WQDVDELLAA
GIDVITTVNV QHVESLNAVV EKITGVAQQE TIPDAVVRAA DEIEVVDLAP QSLRDRLSAG
LVYPAERIDA ALSNYFRLGN LTALRELALL WLADEVDSAL RTYRAEQGIE GTWQARERVV
VALTGGPEGE TLLRRGARIA ARSAGGELLA VHVSAQDGLR DETPGALAAQ RTLVESLGGS
YHQVVGDDIP ATLVEFAQGA DATQLVIGVS RRGRLAAALT GPGIGSEVIR RSGDIDVHIV
THAAAGGRLA LPRMTGGALG WRRQVLGFAV ALVFGPLLSW VMFAFRSPES ITAEVLAYQL
LVVVVALIGG IRPAVFAAVL SGITLDFLFV APLFTITVAH PLHVLALALY VVIAILVSII
VDQAARRART AQRAAAEAEL LAAVAGNVLR GDNAVLAMVS RTREAFGLSG VRLLSPDGDV
LASDGEPVAD GRSTTVPVGV GANGSPRATL ELHGQPLAGP ERRLLDAIVA QLSAAIEHTD
LRATALEAEA LAETDQVRSA LLSAVSHDIR RPLASAVAAI GGLRGAHELS ASDRAELLAT
ADESLATLSA LVTDLLDVSR VQAGVLAVSA TRLDATAPVL AAVDELGLGP SDVELALDSA
LPALHADPVL LQRVLVNVLA NAHRHAPSGS RVLVSTSALG ERAEIRIIDR GAGVAPERRD
SIFQPFQRFG DTDNTTGLGL GLALSRGFTE GMGGTLTPED TPGGGLTMVI SLPLAATSPT
LRQAQESHMT EDTE
//
