ID   A0A0F4JVD3_9ACTN        Unreviewed;       755 AA.
AC   A0A0F4JVD3;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Membrane protein {ECO:0000313|EMBL:KJY37809.1};
GN   ORFNames=VR44_04860 {ECO:0000313|EMBL:KJY37809.1};
OS   Streptomyces katrae.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68223 {ECO:0000313|EMBL:KJY37809.1, ECO:0000313|Proteomes:UP000033551};
RN   [1] {ECO:0000313|EMBL:KJY37809.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL ISP-5550 {ECO:0000313|EMBL:KJY37809.1};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KJY37809.1}.
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DR   EMBL; JZWV01000090; KJY37809.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0F4JVD3; -.
DR   STRING; 68223.GCA_002028425_06966; -.
DR   PATRIC; fig|68223.7.peg.1054; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000033551; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        307..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        535..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        562..582
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        602..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        643..663
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        675..700
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          203..328
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          731..755
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  78208 MW;  504091E9972A577C CRC64;
     MATFLYKTGR FAFRRRGLVT LLWLAVLVAV GLAASTAPPP PADTFSMPGT ESQRAFDVLK
     EKFPAASADG ATARVVVRAP AGQKLSDPAQ KAKVEGLVAA LAKAPDVVSA SDPFKTGTVS
     KDGTTAYAVA GYKVSALKLT DEAHDGLDAV LEKGRADGLT VEAGGDAVKV EAAMGGAEGI
     GILVSAVVLL LTFGSLVAAG MPLLTAVIGV AVGSAAVTAL GSTLGLSATT STLAMMIGLA
     VGIDYALFII SRYRAEVSEG RERADAAGRA VGTAGSAVVF AGLTVIIALA GLAVVNVPML
     TKMGLTAAGT VAIAVLIAVT LVPALLGFAP VKVMPRLERR AIQGKPLTAR LQRRADRLAA
     RTKPNLGTRW AQFVVRRPLL VLAVGVLGLG ALAVPAASLQ LGLPGEGTMA LDTTQRKAYD
     MLSESFGPGF NGPLTVTVQA RDAAAAAGRV GTELAKVEGV ATVTPATPNA AGDTAVLNVV
     PSSGPTEHRT EELVTTIRGM AGAIEADTGA EILVTGQTAL FIDFSRTLDE AMVPYLGLVV
     GLAFLLLVLI FRSLLVPLKA ALGFLLSVSA ALGAVVAVFQ WGWLADVLGI EQPGPVMSTL
     PIFMIGVVFG LAMDYEVFLV TRMREAYVHG ARPTEAVVTG FRYGGRVVSA AAIIMTSVFS
     GFILETNDFV KMVGFSLAAA VLFDAFVVRM ALVPALFALL GRSAWWLPRW LDRLLPNMDV
     EGERLNRTHS VQIAKGGPAA PRPAHRTEAE HDYSV
//