ID A0A0F4KPJ7_9LACO Unreviewed; 748 AA.
AC A0A0F4KPJ7;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN ORFNames=JG29_09940 {ECO:0000313|EMBL:KJY48592.1};
OS Bombilactobacillus mellis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Bombilactobacillus.
OX NCBI_TaxID=1218508 {ECO:0000313|EMBL:KJY48592.1, ECO:0000313|Proteomes:UP000033695};
RN [1] {ECO:0000313|EMBL:KJY48592.1, ECO:0000313|Proteomes:UP000033695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hon2 {ECO:0000313|EMBL:KJY48592.1,
RC ECO:0000313|Proteomes:UP000033695};
RA Ellegaard K.M., Tamarit D., Javelind E., Olofsson T., Andersson S.G.,
RA Vasquez A.;
RT "Comparative genomics of the lactic acid bacteria isolated from the honey
RT bee gut.";
RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KJY48592.1}.
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DR EMBL; JXBZ01000008; KJY48592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F4KPJ7; -.
DR STRING; 1218508.JG29_09940; -.
DR PATRIC; fig|1218508.4.peg.979; -.
DR HOGENOM; CLU_010363_2_3_9; -.
DR Proteomes; UP000033695; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000033695};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 493..696
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 748 AA; 86058 MW; D9F07F13D1C62601 CRC64;
MRRLLLKLNR SSQFDNRGWY IFPVLALQLT LAILVNSFSW PWLILLALLV LTVWQNQRYF
VLLEMLLLIG VGFYLGQKPQ LTLPHNKEII VYPDQIKQKP GWISGTGTLS NGQKVLFGSS
ITKKKNIPAQ VLKIKGDWQW QRIAPATNQG EFDFRKYYQQ QNIYYRATAP KMTITPMLSR
KTLLDYLHLL RYCWLRSFQQ LPHWLRINAC SLLLGDFDTS EVDLRAGLTN LGIIHIFSIS
GLHVYLLVRI LIKLTSFLRI PEESVQLVLF FLLPMFAVIA GSGVGVWRAC GLQMVQIIQS
HFHWPISRHD RFALVLLGQT LFEPYVLFSL AGQLSYLLSY GLIVIRVNKA WQRSLLINFL
SAPVLIFHTY SFGWLTFAAN IFLTPLFEHL IIPLTFLSLL IKKSTQLLQI LESFFDIIYA
PVTALADCNK TQLIVGHLPV MVAMIFVIIT LIVVSNSSHS KYWYTLLLLG YCLVMVGNHF
PSTGQVTLID IGQGDSILLT TPFRRKTCLI DTGGKLRFGR YHSSSNRVEQ ITIPYLKYQG
IDHLDYVFLS HQDADHIGDL QVLLKKFPVR RVCFADGMQN NAAVNRQLNP FRKRVQFCRL
HLNDEIIITP QFKIKVLWPR HLSTGTNEDS LSLLVTIQNI KWLFTGDLNQ ANELKLFKRP
CLIDFFKAGH HGSKTASNPQ FLKMIQPKLV LISAGRHNRY GHPSPETMAT LKKLQIKALS
TAEHGMLTWR YSNWHKPQWQ LFSKEKIK
//
