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Database: UniProt
Entry: A0A0F4R6X3_9GAMM
LinkDB: A0A0F4R6X3_9GAMM
Original site: A0A0F4R6X3_9GAMM 
ID   A0A0F4R6X3_9GAMM        Unreviewed;       514 AA.
AC   A0A0F4R6X3;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=TW85_02105 {ECO:0000313|EMBL:KJZ15721.1};
OS   Marinomonas sp. S3726.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Marinomonas.
OX   NCBI_TaxID=579484 {ECO:0000313|EMBL:KJZ15721.1, ECO:0000313|Proteomes:UP000033747};
RN   [1] {ECO:0000313|EMBL:KJZ15721.1, ECO:0000313|Proteomes:UP000033747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S3726 {ECO:0000313|EMBL:KJZ15721.1,
RC   ECO:0000313|Proteomes:UP000033747};
RX   PubMed=25879706; DOI=10.1186/s12864-015-1365-z;
RA   Machado H., Sonnenschein E.C., Melchiorsen J., Gram L.;
RT   "Genome mining reveals unlocked bioactive potential of marine Gram-
RT   negative bacteria.";
RL   BMC Genomics 16:158-158(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KJZ15721.1}.
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DR   EMBL; JXYC01000004; KJZ15721.1; -; Genomic_DNA.
DR   RefSeq; WP_046015428.1; NZ_JXYC01000004.1.
DR   EnsemblBacteria; KJZ15721; KJZ15721; TW85_02105.
DR   PATRIC; fig|579484.3.peg.435; -.
DR   Proteomes; UP000033747; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000033747};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033747}.
FT   DOMAIN      211    420       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      422    491       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     219    226       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   514 AA;  57880 MW;  6345E52A21DB7E0E CRC64;
     MSLEYWDLCQ KRLQDEFSAQ QFNTWIRPLD AEVNSNGDLI LSAPNRFVLD WVSNKYQTRI
     KELLTEFAGS EPAPVLSFTV RSQGFSKPSA PPAPAPIVET VVTPISEDLS SDVSYRPGFS
     LMEEDTEKHA DLEFEAPLKL SDSGLIGDLE PYKQGQLPLS PSSNRKVDVE GGINHGANLN
     NSFTFDNFVE GKSNQLAHAA ALQVAENPGG AYNPLFIYGG VGLGKTHLMQ AVGTELMRHN
     PNAKVVYLHS ERFVADMVKA LQLNAINDFK RYYRSVDALL IDDIQFFAGK DRTQEEFFHT
     FNALLEGGQQ MILTCDRYPK EIKGLEDRLK SRFGWGLTVA IEPPELETRV AILMRKADES
     NIKLSYDSAF FIAQKIRSNV RELEGALKRV IANSHFTGRA ITPDFVRESL KDLLALQDKL
     VNIDNIQRIV AEYYKIKISD LLSKRRNRSI ARPRQVAMSL AKELTNHSLP EIGDAFGGRD
     HTTALHAIRK IKELQDTDSD IREDYKQLMR ILTT
//
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