UniProt: A0A0F4YWL7

Database: UniProt
Entry: A0A0F4YWL7_TALEM

LinkDB:  A0A0F4YWL7_TALEM 
Original site:  A0A0F4YWL7_TALEM

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (42)   
   InterPro (23)   
   Pfam (10)   
   PROSITE (3)   
   SMART (6)   
All databases (52)   

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ID   A0A0F4YWL7_TALEM        Unreviewed;      2441 AA.
AC   A0A0F4YWL7;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Lovastatin nonaketide synthase {ECO:0000313|EMBL:KKA22033.1};
DE            EC=2.3.1.161 {ECO:0000313|EMBL:KKA22033.1};
GN   ORFNames=T310_3923 {ECO:0000313|EMBL:KKA22033.1};
OS   Rasamsonia emersonii CBS 393.64.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Rasamsonia.
OX   NCBI_TaxID=1408163 {ECO:0000313|EMBL:KKA22033.1, ECO:0000313|Proteomes:UP000053958};
RN   [1] {ECO:0000313|EMBL:KKA22033.1, ECO:0000313|Proteomes:UP000053958}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 393.64 {ECO:0000313|EMBL:KKA22033.1,
RC   ECO:0000313|Proteomes:UP000053958};
RA   Heijne W.H., Fedorova N.D., Nierman W.C., Vollebregt A.W., Zhao Z., Wu L.,
RA   Kumar M., Stam H., van den Berg M.A., Pel H.J.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKA22033.1}.
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DR   EMBL; LASV01000160; KKA22033.1; -; Genomic_DNA.
DR   RefSeq; XP_013328645.1; XM_013473191.1.
DR   STRING; 1408163.A0A0F4YWL7; -.
DR   GeneID; 25316272; -.
DR   OrthoDB; 5396558at2759; -.
DR   Proteomes; UP000053958; Unassembled WGS sequence.
DR   GO; GO:0050637; F:lovastatin nonaketide synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF49; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000313|EMBL:KKA22033.1};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053958};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KKA22033.1}.
FT   DOMAIN          37..455
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2346..2422
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2441 AA;  268479 MW;  2FDF963E19C43105 CRC64;
     MGDCGLNGVY TNATVNGISP LSSSSTSHGT RDREMTVEPI AITGIGLRLP GRIHDASSFW
     KFLTSKGSGR CRVPPDRYNV DAFYRPGKAG HTCTDFGYFL DDVDLATMDT SFWSMSRREV
     EVMDPQQRLM LEVVYECLES PGTTDYKGKA IGCYVGVFGE DWADLQAKDT LNSGPYRVPG
     YGDFAISNRV SYEFGFVGPS MTIRTACSSS LTALYEACQA LYAGECSSAV VGGSNIILSP
     HMTVAMTEQG VLSPTGLCKS FDASADGYAR GEAVNAIYIK KLSDAIRDKD PIRAVIRSAC
     INSDGKTAGW SLPNPRCHEA LIRRSHQIAG ITDLSQTAMI ECHGTGTPVG DPLEAGAVAN
     VFGDWGILIG SVKSNLGHSE GAAGLTGVIK MILALENKAI PPNINFKTPN PKIPFERARM
     RVPVECEAWP EGKAERVGVS SYGIGGANAH VLLDSAASFG IETTKNGLQH DRLPHLLVFS
     ATHVESLRRN IQNIEQYVQS HPSSIRDLSY TLCCRRERFR HRAFAISNAT EDASLDISGL
     KKASQSPTIV FVFTGQGAQY AQMGKDLFLH NAVFVETIKK LDAALKSIDA SISWSLEEEL
     LRAEDESRLS EALFSQPCCT AIQIALVDVL RSINVHPTAV VGHSSGEIAA AYACGSLSAA
     DAIAVAYHRG QVSAKMEKEG KGGMLAVGLS RDAVLKYLTK GIAVGCENSP DNVTLTGESD
     VLDSVAQSIQ NEHPDVLIRR LRVKCAYHSS RMKGVEDEYL SRMNVKTRNL TATFFSSVTG
     EKVMSGDLLG PSYWCSNLTS PVLFSRAVSR LLEDVSPNSV FVEVGPHSAL SGPLRQISQH
     VVRPIQCIST LVRKTNSHEA ILRTAGQLFQ VGAPIDLSPL NPEGGRVLHD LPTYAWNHEG
     RYWSESRLMR GWRMREFPRH DLLGIRITDG SDLEPTWRNV LRLNDTPWLR DHDIMGETVF
     PAAGYVSIAG EAIRQLTGSS DFSVRNVNIL TAMVLQKDAS AEIVTQFRPV RLTTTLNSSS
     WYDFTIASLL DGKWTRNCTG QARPGRDFAI PAAHPEPGVR LVEPDVWYRV MKKFGFNYGP
     RFHGLRDITS SITERKATAR VDDFVDVDNL ESPYTMHPCT IDCIFQLFSV AQCQAIPRLF
     DHLAVPTSIE ELYVCSPSST ISVQASANPM PKGGFFGDAV GFCGDQVVFH LRNMRLSRLT
     DGEERRGVDL HAGAQLVWKP DVDFMDVTSL IRPLQDSAAD NTHLLIEELA LTCMIETEYR
     VQNKVASQPH YAKFQGWLRL QRSNAEQGLY EHVPGCAGIV TMSSEKRVQH VHKLLEKALL
     TEGKKAATAI SSVFEEVVNI FDDKVNPLEL LLKDDLLADI YHFRPLCDYA DFFRLLAHSK
     PNMKILEIGA GTGGMTATIL PVLKNSSPRG ERMYGSYTYT DLSAGFFVAA KERFKDYDAI
     TYRVLDISAD PIVQGFDSES YDLIVASNEL SPTTKWVNYV MGLLPGWWLG EADNRPTEPY
     VSPARWDIEL RNSGFSGAEA VVYDGYLNAH IISSPRKESQ NALEKRVTIL RQSKPSSVAD
     SLHVYLENNG FQINIRFLGG EKVPFGQPVV SVLDLEEEPF IHSLTSDRFD QFKALLLSEL
     EGCPATLWVT RPCQVACTDP RYAMILGLAR TIRTELAMNF ATLELDSFDE AAWSACTKVI
     DKLMERSPDE VLNPVMEFVY SSGTVLTGRF YPVVVGDELL DKAPSTKSVI KKLDIGKRGF
     LQTLAWKQST IEPPQHDDWV EVETRAVGLN FRDVLTAMGV VEAKDLGVEC SGIVTRIGPE
     VKALAPGDHV VVFSGGTFSS ALMTTERLCA KIAANLSFVE AAALPCVFAT VIHSLMDVAR
     LKKGHIYCTV GSAAKVEYLQ NTLGIPRERI FNSRDNTFLR DVLAATDGRG VDVVLNSLSG
     ELLHASWKCV AEFGTMVEIG KRDFIGKASL AMDAFESNRS FVGVDFTRIC AQRPEITQEL
     LKRCMEYFQQ GSITPLPTKE FEAAHVEQAF RYMQKGTHIG KVVVTMPESS AELPSTPAVK
     QLSFRSEGCH IIVGGLGGLG RPVSAWMVMH GARHLVFFSR SSGKNPHHEA FVSELRSQNC
     RVDLVAGDVS SADDVDSLVR DLDVNVAGVM QASMVLKALT GRQDVSLSKM TFNDWQTVVS
     PKVQGTWNLH NALEKCQKKP DYFVLFSSTS GLVGQWGQAN YAAGNTFWTH SSSFDIRVME
     DVGYVSRNDY LLEHFRSTAT HTLQEQDLLE SLHLMIDRSL PSAPEEFDSS AYTSKSQLCI
     GLRTTLPLSL PNNRTVWKRD PRMAIYHNLS SQDRAKSDTH RDDDEALKQF LVEANRRPAM
     LQTPGSAEFL AQHIGRMLFG FMLRDLSDID YDVSLPALGV DSLVAIELRN WFKLKLGLDV
     TVLEILGGAS LTQLGQMSAN NLAKRAAATS STDPSESVGV M
//

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