ID A0A0F7ZNT8_9HYPO Unreviewed; 382 AA.
AC A0A0F7ZNT8;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Sterol 24-C-methyltransferase {ECO:0000256|RuleBase:RU362025};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362025};
DE AltName: Full=Delta(24)-sterol C-methyltransferase {ECO:0000256|RuleBase:RU362025};
GN ORFNames=HIM_06331 {ECO:0000313|EMBL:KJZ74325.1};
OS Hirsutella minnesotensis 3608.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ74325.1, ECO:0000313|Proteomes:UP000054481};
RN [1] {ECO:0000313|EMBL:KJZ74325.1, ECO:0000313|Proteomes:UP000054481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3608 {ECO:0000313|EMBL:KJZ74325.1,
RC ECO:0000313|Proteomes:UP000054481};
RX PubMed=25359922; DOI=10.1093/gbe/evu241;
RA Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA Bushley K.E., Xiang M., Liu X.;
RT "Comparative genomics and transcriptomics analyses reveal divergent
RT lifestyle features of nematode endoparasitic fungus Hirsutella
RT minnesotensis.";
RL Genome Biol. Evol. 6:3077-3093(2014).
CC -!- FUNCTION: Catalyzes the transfer of methyl groups from S-adenosyl-
CC methionine to the C-24 of sterols. {ECO:0000256|RuleBase:RU362025}.
CC -!- PATHWAY: Steroid metabolism. {ECO:0000256|RuleBase:RU362025}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022, ECO:0000256|RuleBase:RU362025}.
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DR EMBL; KQ030527; KJZ74325.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F7ZNT8; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000054481; Unassembled WGS sequence.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Lipid metabolism {ECO:0000256|RuleBase:RU362025};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01022};
KW Steroid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Steroid metabolism {ECO:0000256|RuleBase:RU362025};
KW Sterol biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Sterol metabolism {ECO:0000256|RuleBase:RU362025};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 85..380
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 382 AA; 42574 MW; 7FAA7F1B2FB24EF1 CRC64;
MAPSSTKNNL EREDHSRDAA FNKAMHGKSA QARGGIAAMF AKGGDAKQAA VDEYFKHWDN
KPAADETPEQ RAARTAEYAT LTRHYYNLAT DLYEYGWGQS FHFCRFSTGE PFYQAIARHE
HYLAHSMGIK EGMKVLDVGC GVGGPARQIA KFTGAHITGL NNNDYQIERA THYAAKEGLS
DQLNFVKGDF MQMSFEDNSF DAVYAIEATV HAPTLEGIYS EIFRVLKPGG VFGVYEWLMT
DEYDNDNLHH REIRLGIEQG DGISNMCKVS EALDAMKTAG FELLRNEDLA ERPDPLPWYW
PLSGEMRYIQ TASDIFTIVR MTHWGRAIAH NLAGVLETLR LAPAGTKKTA DSLALAADCL
VAGGREHLFT PMYLMVGRKP AQ
//
