ID A0A0F7ZZ97_9HYPO Unreviewed; 1579 AA.
AC A0A0F7ZZ97;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Integrase catalytic domain-containing protein {ECO:0000259|PROSITE:PS50994};
GN ORFNames=HIM_05429 {ECO:0000313|EMBL:KJZ75235.1}, HIM_06735
GN {ECO:0000313|EMBL:KJZ73842.1}, HIM_08358
GN {ECO:0000313|EMBL:KJZ72216.1}, HIM_10616
GN {ECO:0000313|EMBL:KJZ70005.1}, HIM_11921
GN {ECO:0000313|EMBL:KJZ68686.1};
OS Hirsutella minnesotensis 3608.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Hirsutella.
OX NCBI_TaxID=1043627 {ECO:0000313|EMBL:KJZ73842.1, ECO:0000313|Proteomes:UP000054481};
RN [1] {ECO:0000313|EMBL:KJZ73842.1, ECO:0000313|Proteomes:UP000054481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3608 {ECO:0000313|EMBL:KJZ73842.1,
RC ECO:0000313|Proteomes:UP000054481};
RX PubMed=25359922; DOI=10.1093/gbe/evu241;
RA Lai Y., Liu K., Zhang X., Zhang X., Li K., Wang N., Shu C., Wu Y., Wang C.,
RA Bushley K.E., Xiang M., Liu X.;
RT "Comparative genomics and transcriptomics analyses reveal divergent
RT lifestyle features of nematode endoparasitic fungus Hirsutella
RT minnesotensis.";
RL Genome Biol. Evol. 6:3077-3093(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; KQ030832; KJZ68686.1; -; Genomic_DNA.
DR EMBL; KQ030657; KJZ70005.1; -; Genomic_DNA.
DR EMBL; KQ030550; KJZ72216.1; -; Genomic_DNA.
DR EMBL; KQ030531; KJZ73842.1; -; Genomic_DNA.
DR EMBL; KQ030519; KJZ75235.1; -; Genomic_DNA.
DR OrthoDB; 2538901at2759; -.
DR Proteomes; UP000054481; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR CDD; cd09272; RNase_HI_RT_Ty1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR013103; RVT_2.
DR PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR42648:SF11; TRANSPOSON TY4-P GAG-POL POLYPROTEIN; 1.
DR Pfam; PF07727; RVT_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000054481};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW Transposition {ECO:0000256|ARBA:ARBA00022578}.
FT DOMAIN 580..776
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 261..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1579 AA; 180502 MW; CB0ABCBDF804E845 CRC64;
MKTDTTTRVI LTKPEDWDFW LRQLQARIDE TIHPIVFEDR APKQAPERPE YSSFGNNANV
FTDLSAGQQK TYMNALSDFE SRQKEFLAER KLITAARAIF AETVSKVKLL SLDEDESPYT
WFKRLEKATA PAKGYMLERI KRRYSDHISA TKKTFPEWID QWEEIMQQAK RYFLNEALTG
QWLRDLAAII RPYSDGYATI FRDESRKLDA AAAVIQERLY HSLPPGATAT ESAEGVAAAE
ASEWTLQFAA HRFREIIEFE QQQQRQKTPG VKRGAGFHVD GDEDDQRPSK KKKKTRCLGC
GSTRHGLSDC WSIFEELRPP HMPKNESLIK RAQKALKEDA SLQKKRLLGS RPRRKHGKIV
GIANPAFLYS AEKKSADYPL KNSTLLDSGA SLHICNNLSR FRSFRKARAD FLITGDSEVR
IEGYGRVDVT VTAPDGSKRK LRLKKVAYCP TFSASLVSFQ LLRDEGIFWD TFPTPTRLVH
KSRRPICVLF RVYQQFVLDF RPIKQEDFDE AAFLASKPRR KGSRDPRPTA VADADLWHAR
LGHLGPMALY KLGQRKGLRI KGPKTAECEI CAQGRARRQV SRRPPTRERS YACEEIWIDW
TDLAPSHDEE FGPFLRVMFI TDAFSGMVFP YFLRTYQEKH NWAALRDFVS WMKLRFDCTV
RNVRSDGELF TKKIRNWLRK KGISAEPSAP NTQAQNGGAE RFGGIVIEKA RKMRIAAKLP
HDLWKETVEA ACYVWNRTPR APRPPVDLPS QSASPSDPED QQVLWKTPLE LFTRKDQPEQ
HKHLRAYGCR AYAMTADAQL GRKKLQKLDP RAHIGYLVGY NSTNIFRIWI PQLKKVISTR
DVIFDERTFF DGKREQEPLL ESINQLVQQI SIPESQQKNQ EVLDEETDLE SQLGSDDEDE
VRSTIFVRDE SPEPDEEEED EEEDDGALKR AKELEEASYL TPPEEESYQS ILSVFLPVSS
APKGVGAGTF HALGPSVQVG SEEPFEEPKD RFEDFFPKPI EDGIHGAFTA GRLFKAKARP
HKKDLPDLPQ TLRQLEKHPF REEFTKAQRD HLQSHEEMGT FEEVPWKKAA GKQVLGCKWV
FVYKTDKHGF LQKCKARLVV CGNQQKEGDL PTRATTLAGL SFRALMAIAA EYDLELEQMD
AVNAFVNSPI DEVVFIRMPP GFTRPGRVLL LRKALYGLRR SPLLWQQHLT GSLEALGFEK
VPQEPCVMRK AGVLVFFYVD DFIWAYRKED KEIAKEAMAG LQQRYRMSLL GEPRWFLGIH
ILRDRARKTI WLTQDAYIEK ITHKLIGDPS LLSQRFPDTP MQDEELVPAP IAWQASQKEV
HQFQQKVGSI LFAAISTRPD IAFAVSRLGR QNQNPDSTHQ MAADRVLLYL FATKSYGIRL
GGGEKEAEIF VCSSDSSFAD NSLDRKSSQG YVMTLFGGPI AWRASKQATV ATSSTEAEFL
AISEAAKEAI FLSRLLQSLQ IQIPSPLKLE CDNTQTIRLL EGGSKLSTRL RHVDIHQHWL
RQEIEEGRIR LHWVPTAQMK ADGLTKALPL QKLQSFQRLI GIVDLKDRLW QEARLETLRD
WIAKRDLPLP SCSHARGPV
//
