ID A0A0F8B4B7_CERFI Unreviewed; 920 AA.
AC A0A0F8B4B7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=DNA mismatch repair protein msh-2 {ECO:0000313|EMBL:KKF96651.1};
GN Name=msh-2 {ECO:0000313|EMBL:KKF96651.1};
GN ORFNames=CFO_g999 {ECO:0000313|EMBL:KKF96651.1};
OS Ceratocystis fimbriata f. sp. platani.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Microascales; Ceratocystidaceae; Ceratocystis.
OX NCBI_TaxID=88771 {ECO:0000313|EMBL:KKF96651.1, ECO:0000313|Proteomes:UP000034841};
RN [1] {ECO:0000313|EMBL:KKF96651.1, ECO:0000313|Proteomes:UP000034841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFO {ECO:0000313|EMBL:KKF96651.1,
RC ECO:0000313|Proteomes:UP000034841};
RA Belbahri L.;
RT "Genome sequence of Ceratocystis platani, a major pathogen of plane
RT trees.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKF96651.1}.
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DR EMBL; LBBL01000033; KKF96651.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F8B4B7; -.
DR Proteomes; UP000034841; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000034841}.
FT DOMAIN 731..747
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 920 AA; 103147 MW; 1255DF01FDB9DC0B CRC64;
MSSRPELKVD DEHGFIRFFK SLPECDADTI RIFDGNDFYT AHGSNATFIA KTVYKSTSVI
RQLGRSDDSG LPSVTLSQTV FRQFLREALF KLGKRIEIWA SPNGRMSWKM VKQASPGNLQ
DVEDEIQGQF EAAPMLMAVK ITIKADQRSV GVCFADATVR ELGVSEFLDN DLYSNLESLI
IQLGIKECLV QGEKGEEKDP ELKKVRQIID NCGAAISERP NSEFGVKDIE QDLTRLLKDE
RAVSTLPQSD LKLAMGSAAA LIKYIGALQD PANFGQFHLY QHDLAHYMKL DAAALKALNL
MPGVRDGAKT MSVFGLLNHC KTTAGSRLLS QWLKQPLMDK AEIEKRQQLV DAFFSDTELR
QTMQEEHLRS VPDISRLAKR FQKGKANLED VVRAYQVVIR LPGFIGTLDG VMDDAHREPL
EVAYTNEMRE LSNGLSKLQD LVETTIDLDA LDNHEFIIKA QFDEKLKAIR QKLDHTRREM
DAEFYSSARD LGQERDKKIF MENHKVHGWC MRLTRQEAGC IRNNKDYQEC STQKNGVYFT
TKTLQKLRRE HDQLTEQYNR QQNGLSAEVI KVAASYCPVL GRLAGVLSHL DVIVSLAHCA
VHAPIAYTRP IIHERGQGST ILRESRHPCL EMQDDVQFIT NDIELTRDKS AFLIITGPNM
GGKSTYIRQV GVIALMAQIG SFVPCSEAEV SIFDSILARV GASDSQLKGV STFMAEMLET
ANILKSATGD SLIIIDELGR GTSTYDGFGL AWAISEHIVK EIGCFALFAT HFHELTALAE
SHTQVRNLHV TAHISGIGKD KDEKREVTLL YKVEEGVCDQ SFGIHVAELV RFPDKVVRMA
KRKADELEDF SAKHEDLGIQ YSNDDVAQGS EMLKKLLLEW KKEVASGSLS QAEMVAKMKD
LVMRDKQLLA NPFFQAVKAL
//
