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Database: UniProt
Entry: A0A0F8BCZ1_LARCR
LinkDB: A0A0F8BCZ1_LARCR
Original site: A0A0F8BCZ1_LARCR 
ID   A0A0F8BCZ1_LARCR        Unreviewed;      1427 AA.
AC   A0A0F8BCZ1;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=EH28_05264 {ECO:0000313|EMBL:KKF31724.1};
OS   Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Sciaenidae; Larimichthys.
OX   NCBI_TaxID=215358 {ECO:0000313|EMBL:KKF31724.1, ECO:0000313|Proteomes:UP000054355};
RN   [1] {ECO:0000313|EMBL:KKF31724.1, ECO:0000313|Proteomes:UP000054355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSNF {ECO:0000313|EMBL:KKF31724.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:KKF31724.1};
RX   PubMed=25835551;
RA   Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y.,
RA   Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X.,
RA   Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W.,
RA   Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.;
RT   "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides
RT   Insights into Molecular and Genetic Mechanisms of Stress Adaptation.";
RL   PLoS Genet. 11:E1005118-E1005118(2015).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; KQ041009; KKF31724.1; -; Genomic_DNA.
DR   RefSeq; XP_019110578.1; XM_019255033.1.
DR   GeneID; 109137322; -.
DR   Proteomes; UP000054355; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:InterPro.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 3.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054355};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054355};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     34     54       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    295    320       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    641    663       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    683    698       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    718    741       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1069   1087       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1107   1128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1140   1164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1202   1224       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1303   1327       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        2    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      519    746       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1067   1337       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1336   1363       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1427 AA;  161423 MW;  B45A13D1FAFE7329 CRC64;
     MVILLNCVTL GMYQPCENID CSSDRCQILQ AFDAFIYIFF ALEMVIKMVA RGIFGQRCYL
     GDTWNRLDFF IVMAGMVEYS LDLQNVNFTA IRTVRVLRPL RAINRVPSMR ILVNLLLDTL
     PMLGNVLLLC FFVFFIFGII GVQLWAGLLR NRCYPEENFT RDTGIRLPRP YYMADEDDER
     PFICSLPVDN GIMSCSDVPA RREGGRMCCL DKDDALYRQS LGLSPEPLAN GTDRVAGLCV
     NWNRYYTRCH TGYSNPHKGA INFDNIAYAW IVIFQVITLE GWVEIMYYVM DAHSFYNFIY
     FILLIIVGSF FMINLCLVVI ATQFSETKQR EHQLMQKQRA ECSSNSTMAS EPGDCYEELF
     QLVCHVLRKA RRKTVALFNT LRGKPRGFRG VGRGRGGGEG RERKANGRGG RERRAMRRHG
     APCPHHNKPD HASPMALTTA SATDGCPQCA AALSLTDGVG PVHSTNDEAE EGAVEETDRE
     GEHCSSKEKD KKGQKNQKKS CKDVWHDIRM KLWGIVESKY FNRGIMIAIL INTISMGIEH
     HEQPEELTNV LEICNIVFTS MFSLEMILKI TAFGSFSYLR NPYNVFDGII VIISVCEIVG
     QSDGGLSVLR TFRLLRVLKL VRFMPALRRQ LVVLMKTMDN VATFCMLLML FIFIFSILGM
     HIFGCKFSLR TETGDTVPDR KNFDSLLWAI VTVFQILTQE DWNVVLYNGM AATSPIAALY
     FVALMTFGNY VLFNLLVAIL VEGFQAEGDA NRSYSDDDRS SSNFDESEKH DSIKLSDPRI
     CTLTPNGHLE LGALSGSRGS YSSERRSFTI ESRKSSVMSL GKSSLERRSL SLRHGRSPNY
     HNWGRPFPPQ SAWSRRSSSN SLGRRSYGFG GAPIVGGSLR VHSTRSPHSY PYAAEQESLL
     SHSSHSHHPL HPHHPPPPPS FFSRHFAVRR DRRALSLELP ELHRAGGQPP GLPPVHLDSG
     RRSGSGAGGS ITGGSGAGSG LGVDHRDCNG KTPGPHTQLM AEVFPHVSAR KDRADLDEET
     DYSLCFRIQK MMEVYKPDWC ESREEWSVYL FSPQNKFRLL CQSIIAHKLF DYVVLAFIFL
     NCITVALERP KILQGSLERV FLTISNYIFT AIFVAEMTVK VVSMGLYLGE KAYLRSSWNI
     LDGFLVFVSL IDIVVSMAGG AKILGVLRVL RLLRTLRPLR VISRAPGLKL VVETLITSLK
     PIGNIVLICC AFFIIFGILG VQLFKGKFYY CVGFDVKNIT NKSECLAANY RWVHHKYNFD
     NLGQALMSLF VLASKDGWVN IMYHGLDAVG IDKQPMINNN PWMLLYFISF LLIVSFFVLN
     MFVGVVVENF HKCRQHQEVE EARRREEKRQ RRMEKKRRKA QKLPYYASYG PARLAIHTLC
     TSHYLDLVIT FIICINVITM SLEHYNQPQV TTLLAGDGRA VWVWVLE
//
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