ID A0A0F9ZG77_TRIHA Unreviewed; 380 AA.
AC A0A0F9ZG77;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:KKO99331.1};
GN ORFNames=THAR02_08565 {ECO:0000313|EMBL:KKO99331.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKO99331.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769,
CC ECO:0000256|RuleBase:RU004443}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKO99331.1}.
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DR EMBL; JOKZ01000336; KKO99331.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0F9ZG77; -.
DR OMA; FRYSLDM; -.
DR OrthoDB; 2606404at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR InterPro; IPR004429; Isopropylmalate_DH.
DR NCBIfam; TIGR00169; leuB; 1.
DR PANTHER; PTHR42979; 3-ISOPROPYLMALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR42979:SF4; 3-ISOPROPYLMALATE DEHYDROGENASE; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Branched-chain amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023304};
KW Leucine biosynthesis {ECO:0000256|ARBA:ARBA00022430};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004443};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 6..369
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 380 AA; 40365 MW; B543E144A0FEB711 CRC64;
MAQTFRILVL PGDHVGPEIM AEALKVLDVV EECRPNLKFE RTFDLVGGSS IDKHGVPVTE
EVLDKASKSD AVLFGSVGGP EWANASPNPE AGILGLRQRL DAFANLRPCE ILVPSLLEAS
PLKPDIVKGT KFIVVRENCG GAYFGDKVEK PEVASDLWVY EPREVERCAR VSAAVARILG
KNGDGKGGDG PAIVWSADKA NVLASGRLWR RVTQDIFERE FPDIDLRHQL ADSMAMLMVK
NPRGFNGVIH TDNTFGDILS DISGGIVGSL GTLPSASISG IPGQGKCNGI YEPVHGSAPD
IAGKGIVNPV AQILSLAMLL RYSCVLVDEA AAIEKAVQTV FDSKEAGGLG IRTKDMGGEA
GTKEAGDAIA GEVRRLLQMS
//
