ID A0A0G0ASZ3_TRIHA Unreviewed; 1095 AA.
AC A0A0G0ASZ3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=THAR02_00335 {ECO:0000313|EMBL:KKP07539.1};
OS Trichoderma harzianum (Hypocrea lixii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=5544 {ECO:0000313|EMBL:KKP07539.1, ECO:0000313|Proteomes:UP000034112};
RN [1] {ECO:0000313|Proteomes:UP000034112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA Pe M.E., Sarrocco S., Vannacci G.;
RT "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT T6776.";
RL Genome Announc. 3:E0064715-E0064715(2015).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKP07539.1}.
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DR EMBL; JOKZ01000005; KKP07539.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0ASZ3; -.
DR OMA; HIAPCEL; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000034112; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000034112}.
FT DOMAIN 945..961
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 120884 MW; 55AEBFE526A5EF8D CRC64;
MTPVSKAPEK KQKSLTAFFT PKAVVNGAAP SSRPTVPSSP TPVKEADLPS RKRPLEKDND
MSNGVAEKAA KRTRGDEEND TQSSFFHNDS AVPTTASNRS PASSRAQRYR HDESNSQEDA
GNESDDAQVR RRNEELHRKF VKKLGHPDAL SWRSLKAQDT GADNDEDADA DPEEEEAPIA
TKAKKRGSKT GKLTPMEVQF LDIKRKHMDT ILIVEVGYKF RFFGDDARVA AKELGIVCIP
GKMRYDEHPS EAHLDRFASA SIPVHRLPVH AKRLVAAGHK VGVVRQLETA ALKKAGDNRN
APFVRKLTNL YTKGTYIDEN GELDNQDTST PSGGYLLCIT EMATKGSGTD ENVNVGVLAV
QPATGDIIYD TFEDGFMRSE IETRLLHISP CEFLIVGDLT KGTDKLIQHL SGSSTNVFGD
RSRVERVPKG KTMAAEAYSH VTQFYADQVK EASDNGTASA LLDKVLKLPE AITICLSAMI
THLQEYGLEH IFGLTKYFQS FSTRSHMLIN GTTLESLEVY RNATDHSQKG SLFWAVDKTL
TRFGQRLLRK WVGRPLLDRE RLDERLAAVQ ELLDKQSTSP VDDLERLLTT TKADLERSLI
RIYYGKCTRP ELLSVLQTLQ KIASHYSSVK SASDVGFDSP LIVNAITTLP QILDSVVSYL
ERINLYAAKK DDKYEFFREE FHTEDIQDHQ LGIAHVEHEL DQHRAVAAGK IKQKSVEYVT
VAGIEYLIAV PNKDIKNVPA SWSKISGTKA LSRFHTPEVI RLISERDQHR EALAAACDKA
FKDFLTTIAS EYQPLRDAIS ALATLDCLLS LAKVAAQPGY SRPTFLPSTA EPYISISQGR
HPIAEQTLEG SYIPFTTTLS HPSALAHLIT GPNMGGKSSF VRAVALIVLL SQIGSFVPAD
SLTLTLCDAI HTRAGARDNL FAGESTFMVE VSETARILRS ATPRSLVILD ELGRGTSTHD
GAAIAQSVLQ HVVTDTRCLT LFITHYQNLA RVADGLPGVT NVHMKFNAQT GEDGEEEITF
LYEVGEGIAH RSYGLNVARL ARIPKKVIDV AAGKSKQLEN EMKRRRLQGA YRTLAHVIES
GPDQLDHLIS SIEQL
//
