ID A0A0G0HFU3_9BACT Unreviewed; 710 AA.
AC A0A0G0HFU3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
DE Flags: Fragment;
GN ORFNames=US59_C0039G0001 {ECO:0000313|EMBL:KKQ41072.1};
OS Candidatus Levybacteria bacterium GW2011_GWB1_37_8.
OC Bacteria; Candidatus Levybacteria.
OX NCBI_TaxID=1618463 {ECO:0000313|EMBL:KKQ41072.1, ECO:0000313|Proteomes:UP000033902};
RN [1] {ECO:0000313|EMBL:KKQ41072.1, ECO:0000313|Proteomes:UP000033902}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ41072.1}.
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DR EMBL; LBTO01000039; KKQ41072.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0HFU3; -.
DR STRING; 1618463.US59_C0039G0001; -.
DR Proteomes; UP000033902; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 35..209
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 298..571
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT NON_TER 710
FT /evidence="ECO:0000313|EMBL:KKQ41072.1"
SQ SEQUENCE 710 AA; 78818 MW; 784EB1AA59B7601E CRC64;
MMFFWYSRDL PTPGRLSASN FPQSTKIFDR NGILLYDIYR DENRTYITLD QIPKKLQEAT
IAIEDKDFYK NQGFSIMGYL RAFRNAILSG RIAGGGSTIT QQLVKNTLLT SEQTIVRKIK
EFILAIQVDR KYTKSQILEL YFNATPYGGT TVGVEAAAER YFGKKAKDLD LPESVILAGL
PQRPSYFSPY GQNPKAYIER GKQVLRRMQE DSYITKKQEL DTMKKLPNIV FLKETHAIKA
PHFSFYVKDL LIKQFGENVV EQGGLQVTTT LDYKLEEKAE EIVKEEVQNA ESLKVGNGAS
VVLNPKNGEI LAMVGSRDFF EESDKKEKIP LKGGQFNVIT QALRQPGSSI KPVAYATALE
KGYTASTLIM DTPTNFPGGA QEKDYIPKNY DGKFHGPLQL RFALGSSINI PAVKLLALIG
IKNTLTTAYD MGISTFAPTD DNVNRFGLSL TLGGGDVKPL ELATAYTAFA NQGFKSDPIA
ILKVTDPKGK ILFEQKEVNK KRVLSPEVAY IISHILLDNN ARLITFGSNS YLNVAGLTIA
VKTGTTDDKR DNWTIGWTPN ILVATWVGNN DNSPMGDVAS GVTGAAPIWR RIILEALKGK
PSENFIKPDD VIAITIDSLG GGLPVDGQPT RSEYFIKGTE PQGSSPIYKT IKVSKADGNK
IASQSEIDKN EYDARKFIVF HEDDPTSTDT KNRWQEGIDQ WIADNHKDDS
//
