ID A0A0G0KK53_9BACT Unreviewed; 636 AA.
AC A0A0G0KK53;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=US69_C0004G0043 {ECO:0000313|EMBL:KKQ49559.1};
OS candidate division TM6 bacterium GW2011_GWF2_38_10.
OC Bacteria; Candidatus Dependentiae.
OX NCBI_TaxID=1619084 {ECO:0000313|EMBL:KKQ49559.1, ECO:0000313|Proteomes:UP000034625};
RN [1] {ECO:0000313|EMBL:KKQ49559.1, ECO:0000313|Proteomes:UP000034625}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKQ49559.1}.
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DR EMBL; LBTY01000004; KKQ49559.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0KK53; -.
DR STRING; 1619084.US69_C0004G0043; -.
DR PATRIC; fig|1619084.3.peg.270; -.
DR Proteomes; UP000034625; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF11; PENICILLIN-BINDING PROTEIN 1B; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645,
KW ECO:0000313|EMBL:KKQ49559.1}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 50..225
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 318..566
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 636 AA; 71736 MW; F7769D5516F1FCF5 CRC64;
MVKKIVFGCF FLCCLGLGAL CYLLEKEWVN FSQLGYYSQA KPSIVLDDEG RELARFELDR
RDPVTYDKIP DIIVKAFIAA EDHRFFEHPG ISFKGIIRSF LVNFYHGRVV QGASTITQQL
ARGMFLYHDR TIWRKIQEVF IAFQLERQLS KEQILELYLN NIYFGQGTYG IEAACRRFWN
ISLSDVTTAQ AATLAAVPAS AFLYSPLNAP CSAKKRRNVI IATMQRLGFI GEREALKAKD
EKLVVLDSAQ GNPIRLYIIE WIRVWAESLW GREALYRQGL RIQTTINSDM QTAAEKSFNA
VVAKMNKEME GNFNGGLISL DTATGKIRAA VGGLNFKASQ FNRTFQAYRQ MGSAFKPLLF
AYALERGVEL DQVMIDEPFE LELANGQSWA PRNWHRRFEG PMTLVRALTV SNNVISVKLF
LDLGIPEVVS WMRRFNFKNE LPPYPSAALG TIEATLEETS AAFNSIVNGG VLIKPYLVEW
VKDCWGKKLW MAEPKSTRVM SRTTASKMIN ALSHRMELNK KRTKDGWIDA QSIGKTGSTN
GAATTWFVGA TPSFTTAVYV GRDDNKPMGS RVYASATAYP IWLEFNKAIL HPKKEFYIDP
SLHSVTIDWV TGQSGNYTSV LGYGDVLQKV AILKDL
//
